Tetrahydromethanopterin S-methyltransferase

In enzymology, a tetrahydromethanopterin S-methyltransferase (EC 2.1.1.86) is an enzyme that catalyzes the chemical reaction

tetrahydromethanopterin S-methyltransferase
Identifiers
EC no.2.1.1.86
CAS no.103406-60-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate

Thus, the two substrates of this enzyme are 5-methyl-5,6,7,8-tetrahydromethanopterin and 2-mercaptoethanesulfonate (coenzyme M), whereas its two products are 5,6,7,8-tetrahydromethanopterin and 2-(methylthio)ethanesulfonate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is 5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase. This enzyme is also called tetrahydromethanopterin methyltransferase. This enzyme participates in folate biosynthesis.

References

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  • Sauer FD (April 1986). "Tetrahydromethanopterin methyltransferase, a component of the methane synthesizing complex of Methanobacterium thermoautotrophicum". Biochemical and Biophysical Research Communications. 136 (2): 542–7. doi:10.1016/0006-291X(86)90474-2. PMID 3085670.