Talk:Vesicular monoamine transporter

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VMAT1 in neurons? edit

Latest comment: 8 years ago2 comments1 person in discussion

I am looking up the literature on chromaffine cells and sympathetic neurons with respect to development and differences therein. The review Cell Tissue Res (2015) 359:333–341 DOI 10.1007/s00441-014-1947-0 by K.Huber (Segregation of neuronal and neuroendocrine differentiation in the sympathoadrenal lineage) enforces the notion the Vmat1 is only expressed in chromaffine cells and not in neurons and cites Weihe et al. Journal of Molecular Neuroscience 5(3): 149-164/$7.20 Localization of Vesicular Monoamine Transporter Isoforms (VMATI and VMAT2) to Endocrine Cells and Neurons in Rat. This is in contrast to the sentence: (Location:VMAT1:) It is also expressed in sympathetic neurons and blood platelets. I do not know where this comes from since it is lacking a reference. Please change it or add a citation. --B.Kleine (talk) 08:49, 5 October 2015 (UTC)Reply

I have now got the paper by Brunk et al. It says just the opposite, VMat 2 is expressed in platelets. The paper cites a accessible reference for this: THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278, No. 18, Issue of May 2, pp. 15850–15858, 2003; doi: 10.1074/jbc.M212816200. This is more consistent with latest review on chromaffin cells: Cell Tissue Res (2015) 359:333–341, DOI 10.1007/s00441-014-1947-0, which states that Vmat1 is restricted to chromaffin cells.--B.Kleine (talk) 03:45, 7 October 2015 (UTC)Reply

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