Talk:Trace amine-associated receptor

Latest comment: 6 years ago by Seppi333 in topic Human trace amine-associated receptors

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New review

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It's probably worth using this review to add new content to phenethylamine, 3-iodothyronamine, trace amine, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, and this article. Seppi333 (Insert ) 02:28, 4 February 2017 (UTC)Reply

References

  1. ^ Khan MZ, Nawaz W (October 2016). "The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system". Biomed. Pharmacother. 83: 439–449. doi:10.1016/j.biopha.2016.07.002. PMID 27424325.

Human trace amine-associated receptors

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@Boghog: do you think the content within and layout of this table is suitable for covering these receptors in the article?

Also, do you think it's reasonable to just list "known/putative functions" and "known ligands" as well as explicitly state "other G protein coupling unknown" for these receptors when so few things are actually known about hTAAR2-hTAAR9? Seppi333 (Insert ) 22:30, 15 May 2018 (UTC)Reply

E.g., this review[1] lists "CNS and periphery unknown" under the associated putative functions column in table 1 for all of these receptors, except for TAAR1. Off-topic: I emailed Dr. Berry and he was kind enough to multi-license figure 2 from this review so that I could upload it to Commons and use it in TAAR1. Seppi333 (Insert ) 22:36, 15 May 2018 (UTC)Reply
Hi Seppi333. The lack knowledge about what these receptor subtypes do is of course a direct consequence of a lack of selective ligands to probe their function. The way you have presented this in the table I think is fine. The only suggestion I have is to make clear which of the functions are known and which are putative. Also I found the pink color for pseudogenes distracting and unnecessary. It is clear enough from the text that these are pseudogenes. Boghog (talk) 05:03, 16 May 2018 (UTC)Reply
Sounds good. Removing the coloring is fine with me. Thanks for the feedback! Seppi333 (Insert ) 05:20, 16 May 2018 (UTC)Reply

References

  1. ^ Berry MD, Gainetdinov RR, Hoener MC, Shahid M (December 2017). "Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges". Pharmacology & Therapeutics. 180: 161–180. doi:10.1016/j.pharmthera.2017.07.002. PMID 28723415.