Talk:Muscarine

Untitled

There is an article entitled "Muscarine." However, it is partially obscured by an inserted information block. Someone needs to look into this problem. Thank you. --66.82.9.34 03:55, 20 March 2006 (UTC)

Hemp

Hemp seed contains muscarine. THC (ultraviolet fluoresced CBD) relieves hemp seed poisoning. Atropine also works, but not without toying with you nicotinic receptors. --4.244.215.7 21:12, 1 July 2006 (UTC)Dyjak

Deadly?

The first paragraph states that muscarine is found in mushrooms "such as the deadly C. dealbata." I think this is misleading, as it is rarely deadly, and intoxication lasts only a few hours to a day. The main toxic component is muscarine, so muscarine intoxication causes the symptoms. The muscarine page links to an eMedicine article about muscarine toxicity stating "The prognosis is excellent because most intoxications by muscarine-containing mushrooms are self-limited." (----)MerKaBa —Preceding unsigned comment added by MerKaBa (talk • contribs) 04:50, 8 September 2007 (UTC)

BBB

I'm currently taking a pharmacology course and we're being taught that, unlike choline esters, cholinomimetic alkaloids, such as muscarine, do cross the blood-brain barrier and do have profound CNS effects. Also, I don't think that the logic of the above "Deadly?" discussion holds particularly well--just because the main toxic component of C. dealbata is muscarine, it does not necessarily follow that muscarine intoxication causes the symptoms associated with ingesting the mushroom. It was actually mentioned in said pharm course tangentially that muscarine toxicity was not the primary cause of symptoms associated with muscarine-containing mushroom ingestion, although C. dealbata was not mentioned in particular. Anyone with expertise in this area care to weigh in? 74.60.13.242 03:20, 11 October 2007 (UTC)

Counterion?

The chemical stuff (picture, name) is about a cation, not real substance. What is accompanying counterion in natural environment? — Preceding unsigned comment added by 2.60.46.1 (talk) 05:46, 12 March 2016 (UTC)

Blood-brain barrier

The article states that muscarine can cross the blood-brain barrier. However, I couldn't find any source supporting this. Usually the opposite is said, and it sounds logical because muscarine is not lipophilic. On the other hand, symptoms of "irritability" or "muscle cramps" are sometimes mentioned, which cannot be explained (directly) by the peripheral parasympathomimetic effect. So the blood-brain barrier may be just minimally permeable for muscarine (similarly to the gut)? --79.243.226.23 (talk) 12:27, 31 October 2016 (UTC)

The statement in question has been changed now ("Muscarine does not cross the BBB"). As muscarine is ionic and hydrophilic, this is much more plausible. And irritability and muscle cramps may also be secondary due to loss of fluid (from sweating, vomiting and diarrhea)? --79.243.234.159 (talk) 22:28, 15 January 2017 (UTC)

There's another confusing statement about muscarine potentially causing "convulsions and death". Due to the lack of effect on the CNS and/or neuromuscular junctions, muscarine poisoning should not cause convulsions. At least not directly. Similary to the symptoms discussed above, they could at most occur as a secondary condition (brain damage due to circulatory collapse or lung failure), or if the BBB is compromised. --79.243.251.90 (talk) 20:57, 8 April 2017 (UTC)

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