Talk:Histone deacetylase inhibitor

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Youngblom.m.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 23:30, 16 January 2022 (UTC)

sulphonylpyrroles ?

N-sulphonylpyrrole derivatives may be a separate type of HDI [1] Rod57 (talk) 12:28, 29 October 2009 (UTC)

2nd generation HDIs

What do 2nd generation HDIs bind to, or how are they defined ? Rod57 (talk) 12:12, 13 September 2010 (UTC)

sulforaphane

[2] Rod57 (talk) 03:18, 11 November 2010 (UTC)

Other epigenetic inhibitors

See DNA_methyltransferase#Clinical_significance. Rod57 (talk) 12:01, 29 March 2011 (UTC)

How relevant to breast cancer

Under Cancer treatments it says "Estrogen is well-established as a mitogenic factor implicated in the tumorigenesis and progression of breast cancer via its binding to the estrogen receptor alpha (ERα). Recent data indicate that chromatin inactivation mediated by HDAC and DNA methylation is a critical component of ERα silencing in human breast cancer cells.[30]" but this seems unbalanced here since no HDI has got to phase 3 for breast cancer yet. Perhaps it should be moved to breast cancer research ? - Rod57 (talk) 13:11, 15 April 2016 (UTC)

Possible synergy with PD-1 blockade for cancer

Certain Oncology Agents Enhance Immunotherapy Response in Lung Cancer Mouse Models : ends "These results pave the way for a new clinical application of HDAC inibitors, since so far their use as single agents in solid tumors has not produced positive results. “These results suggest that combination of HDAC inhibitors with PD-1 blockade represents a promising strategy for lung cancer treatment,” senior author Amer Beg said in a press release. A clinical trial is currently recruiting participants to test combination therapy of an HDAC and PD-1 inhibitor in stage 4 non-small cell lung cancer patients." - Can we say why HDI are not effective for solid tumours ? - Rod57 (talk) 13:16, 15 April 2016 (UTC)

Proposed split out of Cancer Treatment section

This section has grown (now 5 approved agents) and seems far more active than use in psychiatry. Propose to split out so future detail doesn't unbalance the main article. Any comments ? - Rod57 (talk) 13:24, 15 April 2016 (UTC)