Talk:Domperidone

Contradictions - OTC or prescription-only in Netherlands? =

At the bottom of the page it is stated: "It is available over-the-counter [...] in [...] Netherlands". However, the sidebar at the top of the page states that the drug is prescription only in the Netherlands. I don't know how to find which is correct or I would edit the page and cite. Does anybody know which it is? 81.107.137.27 (talk) 13:18, 10 June 2020 (UTC)

Promotive

The article has a clear bias in favor of the Jansen pharmaceuticals, Domperidone and ridicules FDA's decision as well as making exaggerated claims such as the ban on this drug results in large imports from Canada. Non-encyclopedic claims are also made such as "prominent" doctors reject FDA's ruling on the drug. Who is a prominent doctor? Is there a list? Claims that the ban on this drug results in foreign illegal imports is a pure speculation and even the source states "The data on the use of domperidone orally as a galactagogue are limited." as well as stating only "some" women tend to import this drug in contrast to this article's tone, designed to create pro-jansen hysteria about this drug. I will remove any unverified or exaggerated claims. --78.86.117.164 15:22, 9 November 2007 (UTC)

Dopamine Beta-Hydroxylase Deficiency

Could domperidone be used as a treatment for Dopamine Beta-Hydroxylase Deficiency... the article states it is an anti-dopaminergic agent... and increases prolactin which is low in people with Dopamine Beta-Hydroxylase Deficiency.... possible treatment? —Preceding unsigned comment added by Interestedperson (talk • contribs) 23:52, 5 October 2008 (UTC)

One article citing Domperidone safety to increase lactation for breastfeeding

To be honest, it's not entirely convincing, but it is out in the literature and probably worth noting.

da Silva et. al., 2001. CMAJ 164(1) 17-21

If no one's done it by then, I'll get the proper links/references up in the next while.

Chansebout (talk) 05:37, 21 November 2008 (UTC)

FDA warning regarding use for lactation stimulation

The original citation ref for the FDA "warning to lactating women" page had gone bad; I replaced it with a version that I think is equivalent, but only glanced at the original citation when the link worked, so could be mistaken. Moppet (talk) 17:41, 4 June 2009 (UTC)

Rationale for FDA decision

It would be helpful if a suitable US based expert editor could explain the concerns of the FDA and the legal position of this drug in the US. This is of particular interest to people outside the US as it is widely available OTC with no apparent health concerns. In the UK it is an OTC (in pharmacies) drug and actually marketed though TV advertising, unusual for most drugs, and advocated for dubious conditions such as 'bloatedness' and 'over-fullness'. --Ef80 (talk) 14:29, 29 December 2009 (UTC)

As so often in Wikipedia, this is US-biased. Domperidone (branded as Motilium) is widely available in in the UK without prescription from pharmacies, but this is not made clear. EnglishBriarRose (talk) 04:22, 5 January 2013 (UTC)

A discussion of how it is used in the UK in regards brain tumour treatment would be useful. It is prescribed as a back up to the anti-sickness tablet Ondansetron when using Temodal (Temozolomide) with Raiation Therapy. — Preceding unsigned comment added by 77.100.235.130 (talk) 13:08, 26 January 2014 (UTC)

Dopaminergic Effects

The article is wrong. According to the pi, motilium is a dopamine antagonist, it blocks dopamine uptake. It is not antidopaminergic. Please find an accurate reference. —Preceding unsigned comment added by Model299 (talk • contribs) 23:38, 16 August 2010 (UTC)

Moved from article

I have moved the following content here because it lacks context/explanation. If anyone wants to use it to improve the article, here it is. -- Ed (Edgar181) 13:51, 24 February 2016 (UTC)

[[File:Domperidone synthesis.svg|thumb|center|700px|Domperidone synthesis:<ref>P. A. J. Janssen, A. H. M. T. Van Heertum, J. Vandenberk, and M. J. M. C. Van der Aa, {{Cite patent|DE|2257261}}; Chem. Abstr., 84, 135657 (1976).</ref><ref>J. Vandenberk et al., {{Cite patent|DE|2632870}}; eidem, {{US patent|4066772}} (1977, 1978 both to [[Janssen Pharmaceutica|Janssen]]).</ref>]]

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Lactation

I came across an article in The Guardian about this drug [1]. Obviously this isn't a WP:MEDRS but I was wondering if such sources exist in regards to this information. If women are dangerously self medicating using the drug and/or there's known side effects regarding suicide ideation and anxiety, that seems like something that ought to be mentioned. Currently the section we have on lactation exclusively mentions positive information. Doc James (let me know if you'd rather not be pinged), any chance you'd have a better idea in regards to MEDRS sourcing on this subject? Clovermoss🍀 (talk) 06:00, 8 June 2024 (UTC)

BNF85 says "SIDE-EFFECTS

▶ Common or very common Dry mouth

▶ Uncommon Anxiety . asthenia . breast abnormalities . diarrhoea . drowsiness . headache . lactation disorders . libido loss

▶ Frequency not known Arrhythmias . depression . gynaecomastia . menstrual cycle irregularities . movement

disorders . oculogyric crisis . QT interval prolongation" Doc James (talk · contribs · email) 07:28, 8 June 2024 (UTC)

So anxiety and depression are mentioned. Doc James (talk · contribs · email) 07:39, 8 June 2024 (UTC)

@Doc James: any chance you'd be willing to add something about this to the article itself? I'd appreciate it immensely. Clovermoss🍀 (talk) 15:14, 8 June 2024 (UTC)

Depression is already listed. Have added anxiety. Doc James (talk · contribs · email) 16:33, 8 June 2024 (UTC)

@Whywhenwhohow: Missed the sample size of three so thank you for catching that [2]. Thoughts on potentially using this source or this one? I really try to not touch biomedical information because I worry about messing it up and not getting all the MEDRS nuances. I'm just slightly concerned that maybe the section as written isn't an accurate reflection of everything. Apart from the mention that it's not approved for offlabel use in the US, there aren't any details given as to the why and the rest of the section provides exclusively positive information. Clovermoss🍀 (talk) 22:05, 8 June 2024 (UTC)

There's also information about possible safety concerns in this context by Health Canada [3]. Clovermoss🍀 (talk) 22:23, 8 June 2024 (UTC)