Talk:Cholesteryl ester transfer protein

Untitled

Many professional publications, including the references, refer to this protein as "cholesteryl ester transfer protein", with a space between cholesteryl and ester. Chemically, I suspect it should be one word. Anyone an idea about this? JFW | T@lk 09:46, 20 November 2005 (UTC)

Should we carry on fiddling with HDL

PMID 17699012 doesn't think so. JFW | T@lk 12:57, 4 November 2007 (UTC)

Homoexchange purpose?

I find the intro paragraph confusing and don't see explanation in the body of text:

• What main purpose does CETP serve?
• What good (to the body) is a homoexchange ("trading a triglyceride for a triglyceride or a cholesteryl ester for a cholesteryl ester") between HDL and VLDL?
• By the description here, both VLDL and HDL are largely unchanged after CETP does its thing. So how does inhibiting CETP change the level of either?
• According to the title of the first ref (Zhong S) increasing CETP function increased HDL. So how does torcetrapib lowering CETP increase HDL?

—(updated) David.Throop (talk) 03:58, 18 November 2007 (UTC)

We need someone who knows the topic to look at the 20 Jan 2012 change. It has to be wrong or the 'or' clause is redundant. But I don't know whether to revert the change or to make it 'trading a triglyceride for a cholesteryl ester or a cholesteryl ester for a triglyceride' I lean towards revert, but.... Thanks — Preceding unsigned comment added by 134.187.128.110 (talk) 00:34, 25 January 2012 (UTC)

Useful source

doi:10.1194/jlr.R400007-JLR200 outlines CETP vs atherosclerosis. This predates the torcetratib debacle. JFW | T@lk 23:57, 2 April 2008 (UTC)

Long Life

There are some rather exciting studies which have CETP linked to long life, good heart health, a reduced risk of cognitive decline with age and a smaller chance of developing Alzheimer's disease. Very cool, if true! It is mentioned in an article in reuters:

http://health.yahoo.com/news/reuters/us_age_genes.html I'd like to see this mentioned (preferably by someone who is very familiar with this sort of science). Gingermint (talk) 19:11, 27 April 2010 (UTC)