SH3 domain-binding protein 4 is a protein that in humans is encoded by the SH3BP4 gene.[5][6]

SH3BP4
Identifiers
AliasesSH3BP4, BOG25, TTP, SH3 domain binding protein 4
External IDsOMIM: 605611; MGI: 2138297; HomoloGene: 8726; GeneCards: SH3BP4; OMA:SH3BP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014521

NM_133816

RefSeq (protein)

NP_598577

Location (UCSC)Chr 2: 234.95 – 235.06 MbChr 1: 89 – 89.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130147Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036206Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dunlevy JR, Berryhill BL, Vergnes JP, SundarRaj N, Hassell JR (Mar 2000). "Cloning, chromosomal localization, and characterization of cDNA from a novel gene, SH3BP4, expressed by human corneal fibroblasts". Genomics. 62 (3): 519–24. doi:10.1006/geno.1999.5994. PMID 10644451.
  6. ^ a b "Entrez Gene: SH3BP4 SH3-domain binding protein 4".

Further reading

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