SC1 or SC-1 may refer to:
- Signal Corps Dirigible No. 1 A 1908 Dirigible built by Thomas Scott Baldwin
- Curtiss SC-1 Seahawk, a version of the American Curtiss SC Seahawk seaplane
- Martin SC-1, a version of the American Curtiss CS reconnaissance and torpedo bomber aircraft
- Short SC.1, the first British fixed-wing vertical take-off and landing (VTOL) aircraft
- Southern Cross Aviation SC-1, an Australian civil aircraft
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