Ribitol-5-phosphate 2-dehydrogenase

In enzymology, a ribitol-5-phosphate 2-dehydrogenase (EC 1.1.1.137) is an enzyme that catalyzes the chemical reaction

ribitol-5-phosphate 2-dehydrogenase
Identifiers
EC no.1.1.1.137
CAS no.37250-67-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
D-ribitol 5-phosphate + NAD(P)+ D-ribulose 5-phosphate + NAD(P)H + H+

The 3 substrates of this enzyme are D-ribitol 5-phosphate, NAD+, and NADP+, whereas its 4 products are D-ribulose 5-phosphate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase. This enzyme is also called dehydrogenase, ribitol 5-phosphate. This enzyme participates in pentose and glucuronate interconversions.

References

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  • Glaser L (April 1963). "Ribitol-5-phosphate dehydrogenase from Lactobacillus plantarum". Biochimica et Biophysica Acta. 67: 525–30. doi:10.1016/0006-3002(63)91863-8. PMID 13948358.