Progesterone 11alpha-monooxygenase

In enzymology, a progesterone 11alpha-monooxygenase (EC 1.14.99.14) is an enzyme that catalyzes the chemical reaction

progesterone 11-alpha-monooxygenase
Identifiers
EC no.1.14.99.14
CAS no.37256-77-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
progesterone + AH2 + O2 11alpha-hydroxyprogesterone + A + H2O

The 3 substrates of this enzyme are progesterone, AH2, and O2, whereas its 3 products are 11alpha-hydroxyprogesterone, A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating). This enzyme is also called progesterone 11alpha-hydroxylase. This enzyme participates in c21-steroid hormone metabolism.

References

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  • Shibahara M, Moody JA, Smith LL (1970). "Microbial hydroxylations. V. 11-alpha-hydroxylation of progesterone by cell-free preparations of Aspergillus ochraceus". Biochim. Biophys. Acta. 202 (1): 172–9. doi:10.1016/0005-2760(70)90228-6. PMID 5417182.