April 4
- 1923 – An F4 tornado tore through parts of Alexandria and Pineville, Louisiana, killing 15 people and injuring 150.
- 1977 – An F5 tornado devastated the northern part of Birmingham, Alabama, killing 22 people and injuring 130.
- 1981 – A highly unusual anticyclonic F4 tornado struck West Bend, Wisconsin, killing three people and injuring 53. It was the strongest anticyclonic tornado on record and the only one known to have caused fatalities. A tornado warning was not issued until 9 minutes after the tornado struck, as the storm that spawned it appeared weak on radar. The tornado lasted only 5 minutes.