April 16
- 1939 – Forty-five people were killed by tornadoes across Texas, Arkansas, and Louisiana. An F4 tornado killed 27 people in Drew County, Arkansas, including 11 in a church near Center Point that had just held a funeral service, and 9 on a single plantation. Another F4 tornado "swept away" a subdivision in Haynesville, Louisiana, killing 8 people.
- 1944 – Two F4 tornadoes struck Georgia and South Carolina, killing 41 people and injuring 320. The first killed 25 people along a 40 mi (64 km) track as moved through Royston and Montevideo, Georgia, and passed near Nuberg, Georgia and Ava, South Carolina. Five people died in one family in Royston. The second tornado killed 16 people, most of them in Abbeville and Greenwood, South Carolina. Most of the dead from this tornado were children.
- 2011 – The third and deadliest day of one of the largest tornado outbreaks on record impacted the Southeastern United States, resulting in 26 deaths. An EF3 tornado killed 12 people in Askewville, North Carolina out of a population of about 240. A long-track EF3 tornado six people in Sanford, North Carolina and Raleigh, North Carolina and moved directly through downtown Raleigh. Four children were killed when a tree fell on a mobile home.
April 17
- 1922 – Twenty people were killed across Illinois and Indiana by a tornado outbreak. An F4 tornado killed 11 people in Hedrick, Indiana after undergoing "rapid and unexpected growth" and two others near Ogden, Illinois. Another F4 tornado swept away homes in Madison and Delaware counties, Indiana, killing 3 people, and carried a postcard 124 miles (200 km).
April 18
- 1880 - A major tornado outbreak killed at least 165 people, primarily in the Midwestern United States. Most of the deaths were from two long-track F4 tornadoes that carved parallel tracks across southern Missouri. The first killed 31 people on a 93 mi (150 km) long path from near Rocky Comfort to near Grove Spring and passing through McDowell. The second devastated Marshfield, destroying all but 15 buildings and killing 92 people in town out of a population of 1,100. The same tornado killed 7 others at Boaz. Another F4 tornado destroyed Barnettsville, Missouri, killing 8 people in town and 6 others elsewhere along its path.
- 1970 – An F4 tornado passed near Clarendon, Texas, killing at least 16 people (Thomas P. Grazulis lists 17 deaths). Thirteen of those deaths were in the mobile home community of Sherwood Shores, where all but one of 172 trailers were destroyed.