|First issue||April 19, 2000|
|Final issue||December 2020 (Print only)|
|Based in||New York City|
It was first published on April 19, 2000. As of June 2004[update], its average paid circulation was over 2.7 million copies, two thirds by subscription. A South African edition was first published in April 2002; according to the South African Advertising Research Foundation, its average readership was over 300,000. The editor of the South African edition is Samantha Page. While most US magazine sales declined in 2009, O Magazine increased its newsstand sales by 5.8 percent to 662,304 copies during the second half of the year. The magazine's newsstand sales fell 15.8% during the first half of 2010, while its subscription circulation increased, and sales fell 8.2% in the later half of the year.
Since its inception until the September 2020 edition, Oprah appeared on the cover of every issue. The first shared cover is her April 2009 issue in which she appears with the First Lady Michelle Obama. The second shared cover is with fellow daytime host Ellen DeGeneres on the December 2009 issue, in which four separate covers were shot for this special holiday issue. For the first time in 20 years of publication, the September 2020 edition featured someone other than Oprah on the cover. This edition featured the late Breonna Taylor, a young woman killed by police in Louisville, Kentucky. 
The magazine serves 63.6% white, 29.8% African-American, 8.8% Hispanic, 1.8% Asian and 6.6% other women. It is directed towards a median age of 47.9, median home value of $214,281, median HHI of $68,911, and median IEI of $38,756.
In July 2020, it was announced that O Magazine will end its regular print publications after the December 2020 issue. The issue featured an article where Oprah thanked readers and also acknowledged it was the magazine's "final monthly print edition."
The December 2010 issue of The Oprah Magazine was the first released digitally through the magazine's iPad app. The app features exclusive videos of Oprah, allows readers to preview and purchase books presented in the magazine's Reading Room and O List sections, and gives users the ability to purchase monthly or yearly subscriptions. Individual issues are also available for download through the app.
In July 2009, Susan Casey became the editor-in-chief of the magazine. Before joining, she was the development editor of Time Inc.. Casey was editor-in-chief of Sports Illustrated Women, editor-at-large for Time Inc., and creative director of Outside. Casey wrote The New York Times bestseller The Devil's Teeth: A True Story of Obsession and Survival Among America's Great White Sharks (2005), and The Wave.
In May 2013, Lucy Kaylin was promoted to editor-in-chief, replacing Susan Casey.
This section needs to be updated.(February 2016)
In 2015, the magazine teamed up with Flatiron Books of St. Martin's Press and published a series of inspirational books, including O's Little Book of Happiness and, in 2016, O's Little Book of Love & Friendship.
This section needs expansion. You can help by adding to it. (March 2011)
In a March 2001 article entitled "O Positive", Noreen O'Leary argued that Winfrey was well on her way to influencing the content of women's magazines beyond her own, just as she has helped reshape daytime TV and the world of book publishing.
In April 2001, Oprah Winfrey and the Hearst Corporation were sued for trademark infringement by Ronald Brockmeyer, the publisher of «O» Magazine, a German erotic periodical that predated Winfrey's magazine by several years. In a March 2003 decision, Judge John Koeltl dismissed the suit, citing the different content of the two magazines in addition to the irregular publication schedule and minimal American sales of the German magazine.
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- Keith J. Kelly (September 11, 2009). "Casey's at the bat at O, The Oprah Magazine". New York Post. Retrieved October 5, 2010.
assumed by Sara Nelson, the mag's new book director...
- Keith j. Kelly (September 10, 2009). "Oprah's O in overhaul". New York Post. Retrieved October 5, 2010.
Sara Nelson was named books editor...
- Lynn Neary (September 10, 2010). "How To Sell A Book? Good Old Word of Mouth". National Public Radio. Retrieved October 5, 2010.
Sara Nelson, book editor at Oprah's O magazine, said ...
- Lucy Kaylin Rises to Editor in Chief at O, The Oprah Magazine; New York Observer; April 28, 2013
- O'Leary, Noreen (2001). "O Positive – O, The Oprah Magazine, profile – Statistical Data Included". Brandweek.