N-acetylglucosamine kinase

In enzymology, a N-acetylglucosamine kinase (EC 2.7.1.59) is an enzyme that catalyzes the chemical reaction

N-acetylglucosamine kinase
N-acetylglucosamine kinase dimer, Thermotoga maritima
Identifiers
EC no.2.7.1.59
CAS no.9027-48-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
ATP + N-acetyl-D-glucosamine ADP + N-acetyl-D-glucosamine 6-phosphate

Thus, the two substrates of this enzyme are ATP and N-acetyl-D-glucosamine, whereas its two products are ADP and N-acetyl-D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acetyl-D-glucosamine 6-phosphotransferase. Other names in common use include acetylglucosamine kinase (phosphorylating), ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase, 2-acetylamino-2-deoxy-D-glucose kinase, and acetylaminodeoxyglucokinase. This enzyme participates in glutamate metabolism and aminosugars metabolism.

References

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  • Asensio C, Ruiz-Amil M (1966). "[76b] N-acetyl-d-glucosamine kinase". N-Acetyl-D-glucosamine kinase. II. Escherichia coli. Methods Enzymol. Vol. 9. pp. 421–425. doi:10.1016/0076-6879(66)09086-4. ISBN 978-0-12-181809-8.
  • Barkulis SS (1966). "[76a] N-Acetyl-d-glucosamine kinase". N-Acetyl-D-glucosamine kinase. I. Streptococcus pyogenes. Methods Enzymol. Vol. 9. pp. 415–420. doi:10.1016/0076-6879(66)09085-2. ISBN 978-0-12-181809-8.
  • Datta A (October 1970). "Studies on hog spleen N-acetylglucosamine kinase. I. Purification and properties of N-acetylglucosamine kinase". Biochimica et Biophysica Acta. 220 (1): 51–60. doi:10.1016/0005-2744(70)90228-7. PMID 4319609.