Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene.[5][6]
Myosin-Ie is a long tailed myosin. It contains an N-terminal motor domain, an IQ motif, a TH1 domain containing a plecstrin homology (PH) domain, a proline rich TH2 domain, and an SH3 domain. [7]
The MYO1E gene was included in several genetic signatures for cancer prognosis.[8]
References edit
- ^ a b c GRCh38: Ensembl release 89: ENSG00000157483 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032220 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, et al. (September 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–439. doi:10.1006/geno.1996.0488. PMID 8884266.
- ^ "Entrez Gene: MYO1E myosin IE".
- ^ McConnell RE, Tyska MJ (July 2010). "Leveraging the membrane - cytoskeleton interface with myosin-1". Trends in Cell Biology. 20 (7): 418–426. doi:10.1016/j.tcb.2010.04.004. PMC 2897960. PMID 20471271.
- ^ Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning". BioData Mining. 15 (1): 28. doi:10.1186/s13040-022-00312-y. eISSN 1756-0381. PMC 9632055. PMID 36329531.
Further reading edit
- Krendel M, Osterweil EK, Mooseker MS (February 2007). "Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis". FEBS Letters. 581 (4): 644–650. doi:10.1016/j.febslet.2007.01.021. PMC 1861834. PMID 17257598.
- El Mezgueldi M, Tang N, Rosenfeld SS, Ostap EM (June 2002). "The kinetic mechanism of Myo1e (human myosin-IC)". The Journal of Biological Chemistry. 277 (24): 21514–21521. doi:10.1074/jbc.M200713200. PMID 11940582.
- Skowron JF, Bement WM, Mooseker MS (1999). "Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells". Cell Motility and the Cytoskeleton. 41 (4): 308–324. doi:10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J. PMID 9858156.
- Robertson H, Langdon WY, Thien CB, Bowtell DD (November 1997). "A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components". Biochemical and Biophysical Research Communications. 240 (1): 46–50. doi:10.1006/bbrc.1997.7608. PMID 9367879.
- Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (July 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6549–6553. Bibcode:1994PNAS...91.6549B. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
- Bement WM, Wirth JA, Mooseker MS (October 1994). "Cloning and mRNA expression of human unconventional myosin-IC. A homologue of amoeboid myosins-I with a single IQ motif and an SH3 domain". Journal of Molecular Biology. 243 (2): 356–363. doi:10.1006/jmbi.1994.1662. PMID 7932763.
External links edit
- Overview of all the structural information available in the PDB for UniProt: E9Q634 (Mouse Unconventional myosin-Ie) at the PDBe-KB.
 | This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it. |