m7G(5')pppN diphosphatase

In enzymology, a m7G(5')pppN diphosphatase (EC 3.6.1.30) is an enzyme that catalyzes the chemical reaction

m7G(5')pppN diphosphatase
Identifiers
EC no.3.6.1.30
CAS no.82599-75-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O 7-methylguanosine 5'-phosphate + polynucleotide

Thus, the two substrates of this enzyme are 7-methylguanosine 5'-triphospho-5'-polynucleotide and H2O, whereas its two products are 7-methylguanosine 5'-phosphate and polynucleotide.

This is the enzyme involved in the processing of amphetamines of the cathinone group, including mephedrone and khat.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase. Other names in common use include decapase, and m7G(5')pppN pyrophosphatase.

See also

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References

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  • Lavers GC (1977). "Cleavage of pm7G from mRNA 5' terminal cap structures by pyrophosphatase activity in embryonic chick lens cells". Mol. Biol. Rep. 3 (6): 413–20. doi:10.1007/BF00808382. PMID 593271.
  • Nuss DL, Altschuler RE, Peterson AJ (1982). "Purification and characterization of the m7G(5')pppN-pyrophosphatase from human placenta". J. Biol. Chem. 257 (11): 6224–30. PMID 6122684.
  • Nuss DL, Furuichi Y (1977). "Characterization of the m7G(5')pppN-pyrophosphatase activity from HeLa cells". J. Biol. Chem. 252 (9): 2815–21. PMID 16003.