Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues. Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs. The most common and severe form is systemic lupus erythematosus.
Signs and symptomsEdit
Symptoms vary from person to person, and may come and go. Almost everyone with lupus has joint pain and swelling. Some develop arthritis. Frequently affected joints are the fingers, hands, wrists, and knees. Other common symptoms include:
- chest pain during respiration
- joint pain
- oral ulcer
- fever with no other cause
- general discomfort, uneasiness, or ill feeling (malaise)
- hair loss
- sensitivity to sunlight
- skin rash – a "butterfly" rash in about half people with SLE
- swollen lymph nodes
- change in autoantibody location
- inducing apoptosis with autoantigens in apoptotic blebs
- upregulation of adhesion molecules and cytokines
- inducing nitric oxide synthase expression
- ultraviolet-generated antigenic DNA.
- tumor necrosis factor alpha also seems to play a role in the development of photosensitivity.
It is typically believed that lupus is influenced by multiple genes. Lupus is usually influenced by gene polymorphisms, 30 of which have now been linked with the disorder. Some of these polymorphisms have been linked very tentatively however, as the role that they play or the degree to which they influence the disease is unknown. Other genes that are commonly thought to be associated with lupus are those in the human leukocyte antigen (HLA) family, which are largely related to healthy functioning of the immune system. There have been several cases where a single gene influence appears to be present, but this is rare. When a single gene deficiency does cause Lupus, it is usually attributed to the genes C1, C2, or C4. The influence of sex chromosomes and environmental factors are also noteworthy. Usually, these factors contribute to Lupus by compromising the immune system. Several studies also indicate a potential association of lupus with mutations in DNA repair genes 
Lupus can develop in any age but most commonly in ages 15 to 44 with varying results. Typically, the manifestation of the disease tends to be more acute in those affected who are of younger age. Women are more likely to get it than men. Patients with juvenile onset Lupus in particular, are vulnerable to mucocutaneous manifestations of the disease (alopecia, skin rash, and ulceration of the mucus membranes) more so than any other age group. However, patients with late onset Lupus have a much higher mortality rate. Nearly 50% of those with late onset Lupus die of their affliction. Women who are of childbearing age are also particularly at risk.
Differences in ethnicityEdit
Substantial data have been found to indicate that certain ethnic populations could be more at risk for Lupus Erythematosus, and have a better or worse prognosis. Asian, African, and Native Americans are more likely to get Lupus than Caucasians. Caucasians seem to generally have a more mild manifestation of the disease. Their survival rates after five years were typically around 94%-96%, while patients of African, and some Asian ethnicities had survival rates closer to 79%-92%. The only documented ethnicity that had a higher survival rate than Caucasians were Koreans, who had survival rates nearer to 98%. Among Caucasians, the most common causes of death were complications involving the cardiovascular system, the respiratory system and problems with malignancies. Atherosclerotic cardiovascular disease is more prevalent in African American Lupus patients compared to Caucasians with Lupus.
For the diagnosis of lupus, four out of 11 signs must be present.
Testing may include:
- Antinuclear antibody (ANA)
- CBC with differential
- Chest X-ray
- Serum creatinine
Of these, systemic lupus erythematosus (also known as SLE) is the most common and serious form.
- acute cutaneous lupus erythematosus
- subacute cutaneous lupus erythematosus
- discoid lupus erythematosus (chronic cutaneous)
- childhood discoid lupus erythematosus
- generalized discoid lupus erythematosus
- localized discoid lupus erythematosus
- chilblain lupus erythematosus (Hutchinson)
- lupus erythematosus-lichen planus overlap syndrome
- lupus erythematosus panniculitis (lupus erythematosus profundus)
- tumid lupus erythematosus
- verrucous lupus erythematosus (hypertrophic lupus erythematosus)
- cutaneous lupus mucinosis
- complement deficiency syndromes
- drug-induced lupus erythematosus
- neonatal lupus erythematosus
- systemic lupus erythematosus
Treatment consists primarily of immunosuppressive drugs (e.g., hydroxychloroquine and corticosteroids). An interesting second line drug is methotrexate in its low-dose schedule. In 2011, the U.S. Food and Drug Administration (FDA) approved the first new drug for lupus in more than 50 years to be used in the US, belimumab. In addition to medicative therapy, due to the psychological and social impacts that lupus may have on an individual, Cognitive Behavioural Therapy (CBT) has also been demonstrated to be effective in reducing stress, anxiety, and depression in lupus sufferers.
People with SLE treated with standard care experience a higher risk of opportunistic infections and death compared with the general population. This risk is higher in men and in African Americans.
- an estimated 5 million people worldwide have some form of lupus disease.
- 70% of lupus cases diagnosed are systemic lupus erythematosus.
- 20% of people with lupus will have a parent or sibling who already has lupus or may develop lupus.
- about 5% of the children born to individuals with lupus will develop the illness.
- SLE affects UK females far more than males at a ratio of 7:1. In other words, females are seven times more likely to have the disease.
- The estimated number of UK females with SLE is 21,700, and the number of UK males with lupus is 3000—a total of 24,700, or 0.041% of the population.
- SLE is more common amongst certain ethnic groups than others, especially those of African origin.
In popular cultureEdit
- In the early seasons of the hit TV show House, the eponymous character's medical team often suggested lupus as a diagnosis for their patients, only to be rebuked. The rarity of legitimate Lupus diagnoses in the show eventually became a running gag.
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- Greco, Carol M; Rudy, Thomas E; Manzi, Susan (2004). "Effects of a stress-reduction program on psychological function, pain, and physical function of systemic lupus erythematosus patients: A randomized controlled trial". Arthritis Care & Research. 51 (4): 625–34. doi:10.1002/art.20533. PMID 15334437.
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- Lai, Zhi-Wei; Kelly, Ryan; Winans, Thomas; Marchena, Ivan; Shadakshari, Ashwini; Yu, Julie; Dawood, Maha; Garcia, Ricardo; Tily, Hajra; Francis, Lisa; Faraone, Stephen V; Phillips, Paul E; Perl, Andras (2018). "Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: A single-arm, open-label, phase 1/2 trial". The Lancet. 391 (10126): 1186–1196. doi:10.1016/S0140-6736(18)30485-9. PMC 5891154. PMID 29551338.
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