Rheumatology (Greek ῥεῦμα, rheûma, flowing current) is a branch of medicine devoted to the diagnosis and therapy of rheumatic diseases. Physicians who have undergone formal training in rheumatology are called rheumatologists. Rheumatologists deal mainly with immune-mediated disorders of the musculoskeletal system, soft tissues, autoimmune diseases, vasculitides, and heritable connective tissue disorders.
|Significant diseases||Rheumatoid arthritis, Systemic lupus erythematosus, Osteoarthritis, Psoriatic arthritis, Ankylosing spondylitis, Gout, Osteoporosis|
|Significant tests||Joint aspirate, Musculoskeletal exam, X-ray|
Beginning in the 2000s, the incorporation of drugs called the biologics (which include inhibitors of TNF-alpha, certain interleukins, and the JAK-STAT signaling pathway) into standards of care is one of the paramount developments in modern rheumatology.
- 1 Rheumatologist
- 2 Diseases
- 3 Diagnosis
- 4 Treatment
- 5 Research directions
- 6 History
- 7 References
- 8 External links
|Names||Doctor, Medical Specialist|
A rheumatologist is a physician who specializes in the field of medical sub-specialty called rheumatology. A rheumatologist holds a board certification after specialized training after attaining a medical degree through fellowship programs in the United States, or specialist registrar positions in the United Kingdom, or DM in India or equivalent programs elsewhere in the world. In the United States, training in this field requires four years undergraduate school, four years of medical school, and then three years of residency, followed by two or three years additional Fellowship training. The requirements may vary in other countries. Rheumatologists are internists who are qualified by additional postgraduate training and experience in the diagnosis and treatment of arthritis and other diseases of the joints, muscles and bones. Many Rheumatologists also conduct research to determine the cause and better treatments for these disabling and sometimes fatal diseases. Treatment modalities are based on scientific research, currently, practice of rheumatology is largely evidence based.
Rheumatologists treat arthritis, autoimmune diseases, pain disorders affecting joints, and osteoporosis. There are more than 200 types of these diseases, including rheumatoid arthritis, osteoarthritis, gout, lupus, back pain, osteoporosis, and tendinitis. Some of these are very serious diseases that can be difficult to diagnose and treat. They treat soft tissue problems related to musculoskeletal system sports related soft tissue disorders.
Diseases diagnosed or managed by rheumatologists include:
- Rheumatoid arthritis
- Juvenile Idiopathic Arthritis (JIA)
- Crystal arthropathies: gout, pseudogout
- Septic arthritis
Systemic conditions and connective tissue diseasesEdit
- Ehlers-Danlos syndrome
- Sjögren's syndrome
- Scleroderma (systemic sclerosis)
- Polymyalgia rheumatica
- Mixed connective tissue disease
- Relapsing polychondritis
- Adult-onset Still's disease
- Myofascial pain syndrome
- Microscopic polyangiitis
- Eosinophilic granulomatosis with polyangiitis (formerly known as Churg–Strauss Syndrome)
- Granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis)
- Polyarteritis nodosa
- Henoch–Schönlein purpura
- Serum sickness
- Giant cell arteritis, Temporal arteritis
- Takayasu's arteritis
- Behçet's syndrome
- Kawasaki's disease (mucocutaneous lymph node syndrome)
- Buerger's disease (thromboangiitis obliterans)
- Hereditary periodic fever syndromes
Soft tissue rheumatismEdit
Local diseases and lesions affecting the joints and structures around the joints including tendons, ligaments capsules, bursae, stress fractures, muscles, nerve entrapment, vascular lesions, and ganglia. For example:
Following are examples of methods of diagnosis able to be performed in a normal physical examination.
- Schober's test tests the flexion of the lower back.
- Multiple joint inspection
- Musculoskeletal Examination
- Screening Musculoskeletal Exam (SMSE) - a rapid assessment of structure and function
- General Musculoskeletal Exam (GMSE) - a comprehensive assessment of joint inflammation
- Regional Musculoskeletal Exam (RMSE) - focused assessments of structure, function and inflammation combined with special testing
- Laboratory tests (e.g. Erythrocyte Sedimentation Rate, Rheumatoid Factor, Anti-CCP (Anti-citrullinated protein antibody), ANA (Anti-Nuclear Antibody) )
- X-rays, Ultrasounds, and other imaging methods of affected joints
- Cytopathology and chemical pathology of fluid aspirated from affected joints (e.g. to differentiate between septic arthritis and gout)
Most rheumatic diseases are treated with analgesics, NSAIDs (nonsteroidal anti-inflammatory drug), steroids (in serious cases), DMARDs (disease-modifying antirheumatic drugs), monoclonal antibodies, such as infliximab and adalimumab, the TNF inhibitor etanercept, and methotrexate for moderate to severe rheumatoid arthritis. The biologic agent rituximab (anti-B cell therapy) is now licensed for use in refractory rheumatoid arthritis.Physiotherapy is vital in the treatment of many rheumatological disorders. Occupational therapy can help patients find alternative ways for common movements which would otherwise be restricted by their disease. Patients with rheumatoid arthritis often need a long term, coordinated and a multidisciplinary team approach towards management of individual patients. Treatment is often tailored according to the individual needs of each patient which is also dependent on the response and the tolerability of medications.
Rheumasurgery - sometimes called rheumatoid surgery - is a subfield of orthopedics occupied with the surgical treatment of patients with rheumatic diseases. The purpose of the interventions is to limit disease activity, soothe pain and improve function.
Rheumasurgical interventions can be divided in two groups. The one is early synovectomies, that is the removal of the inflamed synovia in order to prevent spreading and stop destruction. The other group is the so-called corrective intervention, i.e. an intervention done after destruction has taken place. Among the corrective interventions are joint replacements, removal of loose bone or cartilage fragments, and a variety of interventions aimed at repositioning and/or stabilizing joints, such as arthrodesis.
Recently, a large body of scientific research deals with the background of autoimmune disease, the cause of many rheumatic disorders. Also, the field of osteoimmunology has emerged to further examine the interactions between the immune system, joints and bones. Epidemiological studies and medication trials are also being conducted. Scientific research on biologics and clinical trials on monoclonal antibody therapies have added a new dimension to the medical treatment of arthritic disorders. The Rheumatology Research Foundation is the largest private funding source of rheumatology research and training in the United States.
In 1970 a Norwegian investigation estimated that at least 50% of patients with rheumatic symptoms needed rheumasurgery as an integrated part of their treatment.
The European Rheumatoid Arthritis Surgical Society (ERASS) was founded in 1979.
- Katherine S. Upchurch, Jonathan Kay. "Evolution of treatment for rheumatoid arthritis". Rheumatology (Oxford). 2012 Dec;51 Suppl 6:vi28-vi36. doi:10.1093/rheumatology/kes278.
- "What is a Rheumatologist?". www.rheumatology.org.
- "Methotrexate for rheumatoid arthritis". Arthritis.about.com. Retrieved 2013-06-24.
- Edwards J; Szczepanski L; Szechinski J; Filipowicz-Sosnowska A; et al. (2004). "Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis". N Engl J Med. 350 (25): 2572–2581. doi:10.1056/NEJMoa032534. PMID 15201414.
- "Norsk forening for revmakirurgi - Med hovedbase på Diakonhjemmet" LB Johannessen Tidsskr Nor Lægeforen 2004; 124:3110 Nr. 23 – 2. December 2004
- Rheumakirurgi. Arne Skredderstuen November 2000
- Den sykehusmessige revmatikeromsorgen i Norge (Kåss and Stene 1970), page 24.
- "Surgery for Rheumatic Diseases" Cedars Sinai (http://www.cedars-sinai.edu)
- Revmatisme: Gamle plager - ny viten (Munthe and Larsen 1987), page 49.
- Den sykehusmessige revmatikeromsorgen i Norge (Kåss and Stene 1970), pages 24-25.
- Rydholm, U "Reumakirurgiens uppgång, stabilisering og nedgång ur ett sydsvenskt perspektiv" 2013
- Trender i revmakirurgisk behandling av pasienter med leddgikt og andre kronisk inflammatoriske leddsykdommer, Norsk Rheumabulletin 4/2012, pages 16-17.
- Nikiphorou E, Carpenter L, Morris S, et al. "Hand and foot surgery rates in rheumatoid arthritis have declined from 1986 to 2011, but large-joint replacement rates remain unchanged: results from two UK inception cohorts." Arthritis Rheumatol. 2014;66(5):1081-9. doi:10.1002/art.38344. PMID 24782174