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Lorenzo's Oil is a 1992 American drama film directed by George Miller. It is based on the true story of Augusto and Michaela Odone, two parents in a relentless search for a cure for their son Lorenzo's adrenoleukodystrophy (ALD). It was filmed primarily from September 1991 to February 1992 in Pittsburgh, Pennsylvania. The film had a limited release in North America on December 30, 1992, with a nationwide release two weeks later on January 15, 1993. It was generally well received by the critics and received two nominations at the 65th Academy Awards but was a box office bomb, grossing only $7.2 million against its $30 million budget.
Theatrical release poster
|Directed by||George Miller|
|Produced by||Doug Mitchell|
|Written by||George Miller|
|Music by||Various artists|
|Edited by||Richard Francis-Bruce|
|Distributed by||Universal Pictures|
|Box office||$7.2 million|
Lorenzo is a bright and vibrant young boy living in the Comoro Islands, as his father Augusto works for the World Bank and is stationed there. However, when his parents relocate back to the United States, he begins to show signs of neurological problems (such as falling, loss of hearing, tantrums, etc.). The boy is diagnosed as having adrenoleukodystrophy (ALD), which is fatal within two years. Failing to find a doctor capable of treating their son's rare disease Augusto and his wife, Michaela, set out on a mission to find a treatment to save their son. In their quest, the Odones clash with doctors, scientists and support groups who are skeptical that anything could be done about ALD, much less by laypeople. But they persist, setting up camp in medical libraries, reviewing animal experiments, enlisting the aid of Professor Gus Nikolais, badgering researchers, questioning top doctors all over the world, and even organizing an international symposium about the disease.
Despite research dead-ends, the horror of watching their son's health decline and being surrounded by skeptics (including the coordinators of the support group they attend), they persist until they finally hit upon a therapy involving adding a certain kind of oil (actually containing two specific long chain fatty acids, isolated from rapeseed oil and olive oil) to their son's diet. They contact over 100 firms around the world until they find an elderly British chemist, Don Suddaby, who is working for Croda International and is willing to take on the challenge of distilling the proper formula. The oil, erucic acid, proves successful in normalizing the accumulation of the very long chain fatty acids in the brain that had been causing their son's steady decline, thereby halting the progression of the disease. There is still a great deal of neurological damage remaining which could not be reversed unless new treatments could be found to regenerate the myelin sheath (a lipid insulator) around the nerves. The father is seen taking on the new challenge of organizing biomedical efforts to heal myelin damage in patients.
Finally, Lorenzo, at the age of 14, shows definite improvement (swallowing for himself and answering "yes" or "no" questions by blinking) but more medical research is still needed. Ultimately, it is revealed that Lorenzo has regained his sight, can move his head from side to side, vocalize simple sounds and is learning to use a computer.
- Nick Nolte as Augusto Odone
- Susan Sarandon as Michaela Odone
- Zack O'Malley Greenburg as Lorenzo Odone
- Peter Ustinov as Professor Gus Nikolais
- Kathleen Wilhoite as Deirdre Murphy
- Gerry Bamman as Doctor Judalon
- Margo Martindale as Wendy Gimble
- James Rebhorn as Ellard Muscatine
- Ann Hearn as Loretta Muscatine
- Maduka Steady as Omouri
- Mary Wakio as Comorian Teacher
- Don Suddaby as himself
- Colin Ward as Jake Gimble
- La Tanya Richardson as Nurse Ruth
- Jennifer Dundas as Nurse Nancy Jo
- William Cameron as Pellerman
- Peter Mackenzie as Immunosuppression Doctor
- Laura Linney as Young Teacher
- Elizabeth Daily as vocal effects for Lorenzo
Possibly to emphasize the "Everyman" aspect of the plot (the notion that a cure could affect families and individuals anywhere), many smaller roles were played by inexperienced actors or non-actors with unusual physical features and mannerisms. For example, the poet James Merrill was noticed by a casting director at a New York public reading of his poetry. His rarefied speaking cadences were utilized in a symposium scene in which he played a questioning doctor.
The opening song is "Kijana Mwana Mwali" ("Song about a Young Lady"), sung by the Gonda Traditional Entertainers.
The music for the Easter Midnight Mass scene is a Russian Orthodox Church hymn, "Bogoroditse Devo" (Rejoice, O Virgin) from "Three Choruses from 'Tsar Feodor Ioannovich'", taken from the album Sacred Songs of Russia by Gloriae Dei Cantores.
Roger Ebert of the Chicago Sun Times gave the film four out of four stars and called it an "immensely moving and challenging movie". He added, "it was impossible not to get swept up in it" and James Berardinelli of ReelViews gave it three out of four stars and claimed, "it was about the war for knowledge and the victory of hope through perseverance."Review aggregation website Rotten Tomatoes retrospectively collected reviews from 37 critics to give the film a score of 92%, with an average rating of 8/10, as of June 2019[update].
Though the film seemed to accurately portray the events related to the boy's condition and his parents' efforts during the time period covered by the film, it was criticized for painting a picture of a miracle cure. Subsequent research with Lorenzo's oil has not clearly proven its long-term effectiveness in treating ALD after its onset. The actual subject of the film, Lorenzo Odone, died of pneumonia in May 2008 at the age of 30, having lived two decades longer than originally predicted by doctors.
Awards and honorsEdit
Lorenzo's Oil was nominated twice at the 65th Academy Awards for Best Actress in a Leading Role (Susan Sarandon) and Best Original Screenplay (George Miller & Nick Enright).
Susan Sarandon was nominated for Best Actress in a Drama at the 50th Golden Globe Awards.
The film was nominated for Best Original Screenplay Written Directly for the Screen at the WGA Awards.
Also, the film is recognized by American Film Institute in these lists:
- Voglia di vivere, a 1990 Italian television film depicting the same story.
- Lorenzo, a song by Phil Collins, released on the 1996 album Dance into the Light, is based on a poem Michaela wrote about Lorenzo.
- Extraordinary Measures, a 2010 film depicting the true story of another set of parents' struggle to find a cure for their children's rare disease.
- Paul (film), a 2011 science-fiction comedy film, featuring Jason Bateman as a US Secret Service agent named Lorenzo Zoil.
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- Moser, H. W.; Moser, A. B.; Hollandsworth, K.; Brereton, N. H.; Raymond, G. V. (2007). ""Lorenzo's oil" therapy for X-linked adrenoleukodystrophy: Rationale and current assessment of efficacy". Journal of Molecular Neuroscience. 33 (1): 105–113. doi:10.1007/s12031-007-0041-4. PMID 17901554.
- "Lorenzo loses battle for life but legacy of hope lives on". The Guardian. Guardian News and Media Ltd. 31 May 2008. Retrieved 2012-10-11.
- "Hugo Moser, 82; neurologist's portrayal in `Lorenzo's Oil' belied his real character". Los Angeles Times. 26 January 2007. Retrieved 2017-05-07.
- "Lorenzo's Oil (1992)". IMDB. Retrieved 9 August 2012.
- "Lorenzo's Oil". BoxOfficeMojo. Retrieved 24 September 2012.
- "AFI's 100 Years...100 Cheers Nominees" (PDF). Retrieved 2016-08-14.