Gs alpha subunit
The Gs alpha subunit (Gαs, Gsα, or Gs protein) is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylyl cyclase. It is one of the three main families of G proteins: Gαi/Gαo, Gαq, and Gαs. A mnemonic for remembering this subunit is to look at the first letter (Gαs = Adenylate Cyclase stimulator). In humans it is encoded by the GNAS complex locus.
|, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, POH, SCG6, SgVI, GNAS complex locus, PITA3|
The G protein-coupled receptors that couple to this kind of G-protein include:
- 5-HT receptors types 5-HT4 and 5-HT7
- ACTH receptor a.k.a. MC2R
- Adenosine receptor types A2a and A2b
- Arginine vasopressin receptor 2
- β-adrenergic receptors types β1, β2 and β3
- Calcitonin receptor
- Calcitonin gene-related peptide receptor
- Corticotropin-releasing hormone receptor
- Dopamine receptors D1-like family (D1 and D5)
- Gastric inhibitory polypeptide receptor
- Glucagon receptor
- Growth-hormone-releasing hormone receptor
- Histamine H2 receptor
- Luteinizing hormone/choriogonadotropin receptor
- Melanocortin receptor: MC1R, MC2R (a.k.a. ACTH receptor), MC3R, MC4R, MC5R
- Parathyroid hormone receptor 1
- Prostaglandin receptor types D2 and I2
- Secretin receptor
- Thyrotropin receptor
- Trace amine-associated receptor 1
The general function of Gs is to activate adenylyl cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of Gs are thus found in function of cAMP-dependent protein kinase.
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