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Guanosine diphosphate

Guanosine diphosphate, abbreviated GDP, is a nucleoside diphosphate. It is an ester of pyrophosphoric acid with the nucleoside guanosine. GDP consists of a pyrophosphate group, a pentose sugar ribose, and the nucleobase guanine.[1]

Guanosine diphosphate
Skeletal formula of guanosine diphosphate
Space-filling model of the guanosine diphosphate anion
3D model (JSmol)
Molar mass 443.200522
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

GDP is the product of GTP dephosphorylation by GTPases, e.g., the G-proteins that are involved in signal transduction.

GDP is converted into GTP with the help of pyruvate kinase and phosphoenolpyruvate.

See alsoEdit


  1. ^ Crane, Laura J; Miller, David Lee (1974). "Guanosine triphosphate and guanosine diphosphate as conformation-determining molecules. Differential interaction of a fluorescent probe with the guanosine nucleotide complexes of bacterial elongation factor Tu". Biochemistry. 13 (5): 933–939. doi:10.1021/bi00702a017.