Glycine dehydrogenase (cytochrome)

In enzymology, a glycine dehydrogenase (cytochrome) (EC 1.4.2.1) is an enzyme that catalyzes the chemical reaction

glycine dehydrogenase (cytochrome)
Identifiers
EC no.1.4.2.1
CAS no.9075-55-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
glycine + H2O + 2 ferricytochrome c glyoxylate + NH3 + 2 ferrocytochrome c + 2 H+

The 3 substrates of this enzyme are glycine, H2O, and ferricytochrome c, whereas its 4 products are glyoxylate, NH3, ferrocytochrome c, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with a cytochrome as acceptor. The systematic name of this enzyme class is glycine:ferricytochrome-c oxidoreductase (deaminating). This enzyme is also called glycine---cytochrome c reductase. This enzyme participates in glycine, serine and threonine metabolism.

References

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  • Sanders HK, Becker GE, Nason A (1972). "Glycine-cytochrome c reductase from Nitrobacter agilis". J. Biol. Chem. 247 (7): 2015–25. PMID 5016640.