Glycerol-3-phosphate dehydrogenase 1

Glycerol-3-phosphate dehydrogenase 1 is an enzyme that is encoded by the GPD1 gene in humans.[5]

GPD1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGPD1, GPD-C, GPDH-C, HTGTI, glycerol-3-phosphate dehydrogenase 1
External IDsOMIM: 138420; MGI: 95679; HomoloGene: 5593; GeneCards: GPD1; OMA:GPD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005276
NM_001257199

NM_010271

RefSeq (protein)

NP_001244128
NP_005267

NP_034401

Location (UCSC)Chr 12: 50.1 – 50.11 MbChr 15: 99.62 – 99.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol 3-phosphate (G3P) and NAD+.

The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria.

Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167588Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023019Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Glycerol-3-phosphate dehydrogenase 1". Retrieved 2017-03-23.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.