Glutathione—cystine transhydrogenase

In enzymology, a glutathione—cystine transhydrogenase (EC 1.8.4.4) is an enzyme that catalyzes the chemical reaction

glutathione—cystine transhydrogenase
Identifiers
EC no.1.8.4.4
CAS no.37256-49-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
2 glutathione + cystine glutathione disulfide + 2 cysteine

Thus, the two substrates of this enzyme are glutathione and cystine, whereas its two products are glutathione disulfide and cysteine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is glutathione:cystine oxidoreductase. Other names in common use include GSH-cystine transhydrogenase, and NADPH-dependent GSH-cystine transhydrogenase. This enzyme participates in cysteine metabolism and glutathione metabolism.

References

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  • Nagai S, Black S (1968). "A thiol-disulfide transhydrogenase from yeast". J. Biol. Chem. 243 (8): 1942–7. PMID 5646485.