In enzymology, a glucosylceramidase (EC 18.104.22.168) is an enzyme that catalyzes the chemical reaction
- D-glucosyl-N-acylsphingosine + H2O D-glucose + N-acylsphingosine
Thus, the two substrates of this enzyme are D-glucosyl-N-acylsphingosine and H2O, whereas its two products are D-glucose and N-acylsphingosine.
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is D-glucosyl-N-acylsphingosine glucohydrolase. Other names in common use include:
- psychosine hydrolase,
- glucosphingosine glucosylhydrolase,
- ceramide glucosidase,
- glucosylsphingosine beta-glucosidase,
- and glucosylsphingosine beta-D-glucosidase.
This enzyme participates in sphingolipid metabolism and degradation of glycan structures.