Gamma-glutamylhistamine synthase

In enzymology, a γ-glutamylhistamine synthase (EC 6.3.2.18) is an enzyme that catalyzes the chemical reaction

γ-Glutamylhistamine synthase
Identifiers
EC no.6.3.2.18
CAS no.82904-08-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
ATP + L-glutamate + histamine products of ATP breakdown + Nα-γ-L-glutamylhistamine

The 3 substrates of this enzyme are ATP, L-glutamate, and histamine, whereas its two products are products of ATP breakdown and Nalpha-gamma-L-glutamylhistamine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-glutamate:histamine ligase. Other names in common use include gamma-glutaminylhistamine synthetase, and gamma-GHA synthetase.

References

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  • Stein C, Weinreich D (1982). "An in vitro characterization of gamma-glutamylhistamine synthetase: a novel enzyme catalyzing histamine metabolism in the central nervous system of the marine mollusk, Aplysia californica". J. Neurochem. 38 (1): 204–14. doi:10.1111/j.1471-4159.1982.tb10873.x. PMID 6125565.