Galactose 1-dehydrogenase (NADP+)

In enzymology, a galactose 1-dehydrogenase (NADP+) (EC 1.1.1.120) is an enzyme that catalyzes the chemical reaction

galactose 1-dehydrogenase (NADP+)
Identifiers
EC no.1.1.1.120
CAS no.37250-51-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
D-galactose + NADP+ D-galactono-1,5-lactone + NADPH + H+

Thus, the two substrates of this enzyme are D-galactose and NADP+, whereas its 3 products are D-galactono-1,5-lactone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-galactose:NADP+ 1-oxidoreductase. Other names in common use include D-galactose dehydrogenase (NADP+), and galactose 1-dehydrogenase (NADP+). This enzyme participates in galactose metabolism.

References

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  • Cline AL, Hu AS (1965). "The isolation of three sugar dehydrogenases from a psuedomonad [sic]". J. Biol. Chem. 240 (11): 4488–92. PMID 5845847.
  • Cline AL, Hu AS (1965). "Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240 (11): 4493–7. PMID 5845848.
  • Cline AL, Hu AS (1965). "Some physical properties of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240 (11): 4498–502. PMID 5845849.
  • Schiwara HW, Domagk GF (1968). "Über den Abbau der Desoxyzucker durch Bakterienenzyme, V. Anreicherung und Charakterisierung einer NADP-abhängigen Abequosedehydrogenase aus Pseudomonas putida" [Degradation of deoxysurgars by bacterial enzymes. V. Purification and characterization of an NADP-dependent abequose dehydrogenase from Pseudomonas putida]. Hoppe-Seyler's Z. Physiol. Chem. (in German). 349 (10): 1321–9. doi:10.1515/bchm2.1968.349.2.1321. PMID 4387016.