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Aspartate aminotransferase, cytoplasmic is an enzyme that in humans is encoded by the GOT1 gene.[5][6]

GOT1
Protein GOT1 PDB 1ajr.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGOT1, ASTQTL1, GIG18, cAspAT, cCAT, AST1, glutamic-oxaloacetic transaminase 1
External IDsOMIM: 138180 MGI: 95791 HomoloGene: 1571 GeneCards: GOT1
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for GOT1
Genomic location for GOT1
Band10q24.2Start99,396,870 bp[1]
End99,430,624 bp[1]
RNA expression pattern
PBB GE GOT1 208813 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002079

NM_010324

RefSeq (protein)

NP_002070

NP_034454

Location (UCSC)Chr 10: 99.4 – 99.43 MbChr 19: 43.5 – 43.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.[6]

Interactive pathway mapEdit

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]
Glycolysis and Gluconeogenesis edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120053 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025190 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bousquet-Lemercier B, Pol S, Pave-Preux M, Hanoune J, Barouki R (Sep 1990). "Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection". Biochemistry. 29 (22): 5293–9. doi:10.1021/bi00474a011. PMID 1974457.
  6. ^ a b "Entrez Gene: GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)".

Further readingEdit