XRN1 (gene)

  (Redirected from Exoribonuclease I)

5'-3' exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. Xrn1 hydrolyses RNA in the 5’ to 3’ direction.[5][6]

XRN1
Identifiers
AliasesXRN1, SEP1, 5'-3' exoribonuclease 1
External IDsOMIM: 607994 MGI: 891964 HomoloGene: 5894 GeneCards: XRN1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for XRN1
Genomic location for XRN1
Band3q23Start142,306,607 bp[1]
End142,448,062 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042604
NM_001282857
NM_001282859
NM_019001

NM_011916
NM_001311130

RefSeq (protein)

NP_001269786
NP_001269788
NP_061874

n/a

Location (UCSC)Chr 3: 142.31 – 142.45 MbChr 9: 95.95 – 96.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FunctionEdit

This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including transcription, translation, homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

See alsoEdit

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114127 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032410 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mullen TE, Marzluff WF (January 2008). "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'". Genes & Development. 22 (1): 50–65. doi:10.1101/gad.1622708. PMC 2151014. PMID 18172165.
  6. ^ "Entrez Gene: 5'-3' exoribonuclease 1".

Further readingEdit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.