Wikipedia

Draft:Chinfei Chen


Introduction edit

Chinfei Chen is an American neuroscientist and member of the American Academy of Arts and Sciences studying synaptic plasticity.[1][2][3][4][5][6] She currently serves as a professor of neurology at Harvard Medical School[7] and the associate director of the Harvard Program in Neuroscience.[8]

Early Life edit

Chinfei Chen, born to Taiwanese immigrants, spent her early years in Wilmington, Delaware.[9] Her father had previously moved to the United States to pursue a graduate degree in architecture.[9] As Chen grew older, she and her family relocated to New York City, where she received her education through the city's public school system.[9]

Education and Career edit

While in New York, Chen went to Stuyvesant High School.[9] She attended the University of Pennsylvania to pursue a Bachelor of Applied Science in engineering.[9] During her undergraduate years, she joined Britton Chance's laboratory, where she studied flavoproteins in the brain.[9] Chen later obtained her M.D. and Ph.D. from Harvard Medical School.[9] While in medical school, she worked with Edward Kravitz to research neurotransmitter signaling pathways in lobsters.[9] She also worked with Peter Hess on calcium channel biophysics for her Ph.D. Chen then completed her residency in adult neurology at Massachusetts General Hospital.[9][10], followed by postdoctoral training with Wade Regehr at Harvard Medical School.[9][10] She is currently a professor of neurology at Harvard Medical School[11], and the associate director of the Harvard Graduate Program in Neuroscience[11]. Furthermore, Chen also works as a Research Associate in Neurology at the Boston Children's Hospital[8].

Research edit

Chen's first experience in a research lab was spent observing fluorescent activity in rat brains as a measurement for metabolic activity.[9] She did her residency at Mass General and decided to study the thalamus during her postdoctoral training.[9] Chen's research focuses on mechanisms of synaptic and circuit plasticity in the mammalian central nervous system, for which she was recognized by the AAAS.[12][1] Chen's research includes the study of boutons that send information to the thalamus.[12] Chen's research projects have also focused on Autism, specifically in relation to the corticothalamic circuit interactions in Autism. [13]

Personal Life edit

In her free time outside of the lab, Chen gardens and creates floral arrangements and is a fan of Boston Red Sox.[9] After being gifted hockey gear from her husband, Chen learned how to play ice hockey and enjoys the sport for exercise.[9]

Selected Publications[5] edit

  • Taub, D. G., Jiang, Q., Pietrafesa, F., Su, J., Carroll, A., Greene, C., Blanchard, M. R., Jain, A., El-Rifai, M., Callen, A., Yager, K., Chung, C., He, Z., Chen, C., & Woolf, C. J. (2024, February 12). The secondary somatosensory cortex gates mechanical and heat sensitivity. Nature Communications. https://doi.org/10.1038/s41467-024-45729-7
  • Tzeng, C. P., Whitwam, T., Boxer, L. D., Li, E., Silberfeld, A., Trowbridge, S., Mei, K., Lin, C., Shamah, R., Griffith, E. C., Renthal, W., Chen, C., & Greenberg, M. E. (2023, October 23). Activity-induced MeCP2 phosphorylation regulates retinogeniculate synapse refinement. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2310344120
  • Liang, L., & Chen, C. (2020, September 15). Organization, Function, and Development of the Mouse Retinogeniculate Synapse. Annual Review of Vision Science. https://doi.org/10.1146/annurev-vision-121219-081753
  • Chen, D., Liu, Y., Shu, G., Chen, C., Sullivan, D. A., Kam, W. R., Hann, S., Fowler, M. E., & Warman, M. L. (2020, May 21). Ocular Manifestations of Chordin-like 1 Knockout Mice. Cornea. https://doi.org/10.1097/ico.0000000000002371
  • Liu, Y., Latrémolière, A., Li, X., Zhang, Z., Chen, M., Wang, X., Fang, C., Zhu, J., Alexandre, C., Gao, Z., Chen, B., Ding, X., Zhou, J., Zhang, Y., Chen, C., Wang, K. H., Woolf, C. J., & He, Z. (2018, September 1). Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature. https://doi.org/10.1038/s41586-018-0515-2
  • Hong, Y. K., Burr, E., Sanes, J. R., & Chen, C. (2018, August 7). Heterogeneity of retinogeniculate axon arbors. European Journal of Neuroscience/EJN. European Journal of Neuroscience. https://doi.org/10.1111/ejn.13986
  • Litvina, E. Y., & Chen, C. (2017, January 1). An evolving view of retinogeniculate transmission. Visual Neuroscience. https://doi.org/10.1017/s0952523817000104
  • Thompson, A., & Chen, C. (2017, January 1). The importance of constructive feedback: Implications of top-down regulation in the development of neural circuits. Neurogenesis. https://doi.org/10.1080/23262133.2017.1287553
  • Hauser, J. L., Liu, X., Litvina, E. Y., & Chen, C. (2014, October 1). Prolonged synaptic currents increase relay neuron firing at the developing retinogeniculate synapse. Journal of Neurophysiology. https://doi.org/10.1152/jn.00451.2014
  • Lin, D. J., Kang, E., & Chen, C. (2014, August 15). Changes in input strength and number are driven by distinct mechanisms at the retinogeniculate synapse. Journal of Neurophysiology. https://doi.org/10.1152/jn.00175.2014
  • Chung, W., Clarke, L., Wang, G., Stafford, B. K., Sher, A., Chakraborty, C., Joung, J., Foo, L. C., Thompson, A., Chen, C., Smith, S. J., & Barres, B. A. (2013, November 24). Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature. https://doi.org/10.1038/nature12776
  • Kang, E., Durand, S., LeBlanc, J. J., Hensch, T. K., Chen, C., & Fagiolini, M. (2013, November 6). Visual Acuity Development and Plasticity in the Absence of Sensory Experience. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.1500-13.2013
  • Hauser, J. L., Edson, E. B., Hooks, B. M., & Chen, C. (2013, January 1). Metabotropic glutamate receptors and glutamate transporters shape transmission at the developing retinogeniculate synapse. Journal of Neurophysiology. https://doi.org/10.1152/jn.00897.2012
  • Roy, K., Murtie, J., El‐Khodor, B. F., Edgar, N., Sardi, S. P., Hooks, B. M., Benoît-Marand, M., Chen, C., Moore, H., O’Donnell, P., Brunner, D., & Corfas, G. (2007, May 8). Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.0702157104
  • Chen, D., Liu, Y., Shu, G., Chen, C., Sullivan, D. A., Kam, W. R., Hann, S., Fowler, M. E., & Warman, M. L. (2020, May 21). Ocular Manifestations of Chordin-like 1 Knockout Mice. Cornea. https://doi.org/10.1097/ico.0000000000002371

References edit

  1. ^ a b "2024 New Member List | American Academy of Arts and Sciences". www.amacad.org. Retrieved 2024-04-29.
  2. ^ "Newsroom | Two Boston Children's Hospital Researchers Elected to The American Academy of Arts & Sciences | Boston Children's Hospital". www.childrenshospital.org. Retrieved 2024-04-29.
  3. ^ "2024 New Member List | American Academy of Arts and Sciences". www.amacad.org. Retrieved 2024-04-29.
  4. ^ "News & Research". hms.harvard.edu. Retrieved 2024-04-29.
  5. ^ a b "Chen, Chinfei[Full Author Name] - Search Results - PubMed". PubMed. Retrieved 2024-04-26.
  6. ^ "Balancing the Brain | Nursing Today. Nursing Journals : American Society of Registered Nurses". www.asrn.org. Retrieved 2024-04-29.
  7. ^ "Rett protein alters visual circuits in mice". Spectrum | Autism Research News. 2011-05-23. Retrieved 2024-04-29.
  8. ^ a b "Chinfei Chen". Harvard Brain Science Initiative. Retrieved 2024-04-26.
  9. ^ a b c d e f g h i j k l m n "Episode 24: Chinfei Chen, MD PhD". Conjugate: Illustration and Science Blog. Retrieved 2024-04-26.
  10. ^ a b "Chinfei Chen". ERM 2019. Retrieved 2024-04-29.
  11. ^ a b "Chinfei Chen". dms.hms.harvard.edu. Retrieved 2024-04-26.
  12. ^ a b "Scientists Visualize the Connections Between Eye and Brain". www.bidmc.org. Retrieved 2024-04-29.
  13. ^ "2024 Thalamocortical Interactions Conference GRC". www.grc.org. Retrieved 2024-04-29.
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