In enzymology, a deoxyadenosine kinase (EC 2.7.1.76) is an enzyme that catalyzes the chemical reaction

deoxyadenosine kinase
Identifiers
EC no.2.7.1.76
CAS no.37278-12-9
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
ATP + deoxyadenosine ADP + dAMP

Thus, the two substrates of this enzyme are ATP and deoxyadenosine, whereas its two products are ADP and dAMP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:deoxyadenosine 5'-phosphotransferase. This enzyme is also called purine-deoxyribonucleoside kinase. This enzyme participates in purine metabolism.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JAQ.

References

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  • Chang CH, Brockman RW, Bennett LL (1982). "Purification and some properties of a deoxyribonucleoside kinase from L1210 cells". Cancer Res. 42 (8): 3033–9. PMID 6284353.
  • Krygier V, Momparler RL (1968). "The regulatory properties of deoxyadenosine kinase". Biochim. Biophys. Acta. 161 (2): 578–80. doi:10.1016/0005-2787(68)90139-1. PMID 5667299.