In enzymology, a dCTP deaminase (EC 3.5.4.13) is an enzyme that catalyzes the chemical reaction

dCTP deaminase
Identifiers
EC no.3.5.4.13
CAS no.37289-18-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
dCTP + H2O dUTP + NH3

Thus, the two substrates of this enzyme are dCTP and H2O, whereas its two products are dUTP and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase. Other names in common use include deoxycytidine triphosphate deaminase, and 5-methyl-dCTP deaminase. This enzyme participates in pyrimidine metabolism.

Structural studies

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As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1OGH, 1PKH, 1PKJ, 1PKK, 1XS1, 1XS4, 1XS6, 2J4H, and 2J4Q.

References

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  • Tomita F, Takahashi I (1969). "A novel enzyme, dCTP deaminase, found in Bacillus subtilis infected with phage PBS I". Biochim. Biophys. Acta. 179 (1): 18–27. doi:10.1016/0005-2787(69)90117-8. PMID 4976547.