D-methionine—pyruvate transaminase

In enzymology, a D-methionine—pyruvate transaminase (EC 2.6.1.41) is an enzyme that catalyzes the chemical reaction

D-methionine-pyruvate transaminase
Identifiers
EC no.2.6.1.41
CAS no.37277-93-3
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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Gene OntologyAmiGO / QuickGO
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NCBIproteins
D-methionine + pyruvate 4-methylthio-2-oxobutanoate + L-alanine

Thus, the two substrates of this enzyme are D-methionine and pyruvate, whereas its two products are 4-methylthio-2-oxobutanoate and L-alanine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is D-methionine:pyruvate aminotransferase. Other names in common use include D-methionine transaminase, and D-methionine aminotransferase. This enzyme participates in d-alanine metabolism.

References

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  • Mapson LW, March JF, Wardale DA (1969). "Biosynthesis of ethylene. 4-methylmercapto-2-oxobutyric acid: an intermediate in the formation from methionine". Biochem. J. 115 (4): 653–61. PMC 1185190. PMID 5357015.