D-iditol 2-dehydrogenase

In enzymology, a d-iditol 2-dehydrogenase (EC 1.1.1.15) is an enzyme that catalyzes the chemical reaction

d-iditol 2-dehydrogenase
Identifiers
EC no.1.1.1.15
CAS no.9028-22-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
d-iditol + NAD+ d-sorbose + NADH + H+

Thus, the two substrates of this enzyme are d-iditol and NAD+, whereas its 3 products are d-sorbose, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is d-iditol:NAD+ 2-oxidoreductase. This enzyme is also called d-sorbitol dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.

References

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  • Shaw DR (November 1956). "Polyol dehydrogenases. 3. Galactitol dehydrogenase and D-iditol dehydrogenase". The Biochemical Journal. 64 (3): 394–405. PMC 1199749. PMID 13373783.