Chalcone isomerase

In enzymology, a chalcone isomerase (EC 5.5.1.6) is an enzyme that catalyzes the chemical reaction

chalcone isomerase
Identifiers
EC no.5.5.1.6
CAS no.9073-57-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Chalcone isomerase
PDB 1jep EBI.jpg
chalcone isomerase complexed with 4'-hydroxyflavanone
Identifiers
SymbolChalcone
PfamPF02431
InterProIPR003466
SCOP21eyp / SCOPe / SUPFAM
a chalcone a flavanone

Hence, this enzyme has one substrate, a chalcone, and one product, a flavanone.

This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is flavanone lyase (decyclizing). This enzyme is also called chalcone-flavanone isomerase. This enzyme participates in flavonoid biosynthesis.

The Petunia hybrida (Petunia) genome contains two genes coding for very similar enzymes, ChiA and ChiB, but only the first seems to encode a functional chalcone isomerase.

Structural studiesEdit

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1EYP, 1EYQ, 1FM7, 1FM8, 1JEP, 1JX0, and 1JX1.

Chalcone isomerase has a core 2-layer alpha/beta structure consisting of beta(3)-alpha(2)-beta-alpha(2)-beta(3).[1]

ReferencesEdit

  1. ^ Jez JM, Bowman ME, Dixon RA, Noel JP (September 2000). "Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase". Nat. Struct. Biol. 7 (9): 786–91. doi:10.1038/79025. PMID 10966651. S2CID 22198011.

Further readingEdit

This article incorporates text from the public domain Pfam and InterPro: IPR003466