Cephalosporin-C transaminase

In enzymology, a cephalosporin-C transaminase (EC 2.6.1.74) is an enzyme that catalyzes the chemical reaction

cephalosporin-C transaminase
Identifiers
EC no.2.6.1.74
CAS no.122096-91-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
(7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate cephalosporin C + 2-oxoglutarate

Thus, the two substrates of this enzyme are (7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate and D-glutamate, whereas its two products are cephalosporin C and 2-oxoglutarate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is cephalosporin-C:2-oxoglutarate aminotransferase. Other names in common use include cephalosporin C aminotransferase, and L-alanine:cephalosporin-C aminotransferase. This enzyme participates in penicillin and cephalosporin biosynthesis.

References

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  • Aretz W, Sauber K (1988). "Novel D-amino acid transaminase". Ann. N. Y. Acad. Sci. 542: 366–70. PMID 3228235.