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Centromere protein F is a protein that in humans is encoded by the CENPF gene.[5][6][7]

CENPF
Identifiers
AliasesCENPF, CENF, PRO1779, hcp-1, CILD31, STROMS, centromere protein F
External IDsMGI: 1313302 HomoloGene: 22969 GeneCards: CENPF
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CENPF
Genomic location for CENPF
Band1q41Start214,603,195 bp[1]
End214,664,571 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016343

NM_001081363

RefSeq (protein)

NP_057427

n/a

Location (UCSC)Chr 1: 214.6 – 214.66 MbChr 1: 189.64 – 189.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.[7]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117724 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026605 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Rattner JB, Rao A, Fritzler MJ, Valencia DW, Yen TJ (Mar 1994). "CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization". Cell Motil Cytoskeleton. 26 (3): 214–26. doi:10.1002/cm.970260305. PMID 7904902.
  6. ^ Testa JR, Zhou JY, Bell DW, Yen TJ (Mar 1995). "Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24→q25 and 1q32→q41, respectively, by fluorescence in situ hybridization". Genomics. 23 (3): 691–3. doi:10.1006/geno.1994.1558. PMID 7851898.
  7. ^ a b "Entrez Gene: CENPF centromere protein F, 350/400ka (mitosin)".

External linksEdit

Further readingEdit