Calmodulin 2 is a protein that in humans is encoded by the CALM2 gene.[3][4]

Protein CALM2 PDB 1a29.png
Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesCALM2, CAMII, PHKD, PHKD2, LQT15, caM, calmodulin 2 (phosphorylase kinase, delta), calmodulin 2, CAMC, CAM1, CAMIII, CAM3, CALM, CALML2
External IDsOMIM: 114182 HomoloGene: 134804 GeneCards: CALM2
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for CALM2
Genomic location for CALM2
Band2p21Start47,160,083 bp[1]
End47,176,921 bp[1]
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC)Chr 19: 47.16 – 47.18 Mbn/a
PubMed search[2]n/a
View/Edit Human

Clinical significanceEdit

Mutations in CALM2 are associated to cardiac arrhythmias.[5]


CALM2 has been shown to interact with AKAP9.[6][7]

See alsoEdit


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143933 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: CALM2 Calmodulin 2 (phosphorylase kinase, delta)".
  4. ^ SenGupta B, Friedberg F, Detera-Wadleigh SD (December 1987). "Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species". J. Biol. Chem. 262 (34): 16663–70. PMID 2445749.
  5. ^ Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kääb S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ, George AL (2014). "Novel calmodulin mutations associated with congenital arrhythmia susceptibility". Circ Cardiovasc Genet. 7 (4): 466–74. doi:10.1161/CIRCGENETICS.113.000459. PMC 4140998. PMID 24917665.
  6. ^ Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (Sep 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
  7. ^ Berchtold MW, Egli R, Rhyner JA, Hameister H, Strehler EE (May 1993). "Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3". Genomics. 16 (2): 461–5. doi:10.1006/geno.1993.1211. PMID 8314583.

External linksEdit

Further readingEdit