A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a damage in the continuity of the bone. A bone fracture may be the result of high force impact or stress, or a minimal trauma injury as a result of certain medical conditions that weaken the bones, such as osteoporosis, bone cancer, or osteogenesis imperfecta, where the fracture is then properly termed a pathologic fracture.
|Synonyms||broken bone, bone break|
|Internal and external views of an arm with a compound fracture, both before and after surgery|
|Classification and external resources|
|ICD-10||Sx2 (where x=0–9 depending on the location of the fracture)|
Signs and symptomsEdit
- Breaking in the continuity of the periosteum, with or without similar discontinuity in endosteum, as both contain multiple pain receptors
- Edema of nearby soft tissues caused by bleeding of torn periosteal blood vessels evokes pressure pain
- Muscle spasms trying to hold bone fragments in place. Sometimes also followed by cramping
Damage to adjacent structures such as nerves or vessels, spinal cord, and nerve roots (for spine fractures), or cranial contents (for skull fractures) may cause other specific signs and symptoms.
The natural process of healing a fracture starts when the injured bone and surrounding tissues bleed, forming a fracture hematoma. The blood coagulates to form a blood clot situated between the broken fragments. Within a few days, blood vessels grow into the jelly-like matrix of the blood clot. The new blood vessels bring phagocytes to the area, which gradually remove the non-viable material. The blood vessels also bring fibroblasts in the walls of the vessels and these multiply and produce collagen fibres. In this way the blood clot is replaced by a matrix of collagen. Collagen's rubbery consistency allows bone fragments to move only a small amount unless severe or persistent force is applied.
At this stage, some of the fibroblasts begin to lay down bone matrix in the form of collagen monomers. These monomers spontaneously assemble to form the bone matrix, for which bone crystals (calcium hydroxyapatite) are deposited in amongst, in the form of insoluble crystals. This mineralization of the collagen matrix stiffens it and transforms it into bone. In fact, bone is a mineralized collagen matrix; if the mineral is dissolved out of bone, it becomes rubbery. Healing bone callus on average, is sufficiently mineralized to show up on X-ray within 6 weeks in adults and less in children. This initial "woven" bone does not have the strong mechanical properties of mature bone. By a process of remodeling, the woven bone is replaced by mature "lamellar" bone. The whole process may take up to 18 months, but in adults, the strength of the healing bone is usually 80% of normal by 3 months after the injury.
Several factors may help or hinder the bone healing process. For example, any form of nicotine hinders the process of bone healing, and adequate nutrition (including calcium intake) will help the bone healing process. Weight-bearing stress on bone, after the bone has healed sufficiently to bear the weight, also builds bone strength.
Effects of smokingEdit
Smokers generally have lower bone density than non-smokers, so have a much higher risk of fractures. There also is evidence that smoking delays bone healing.
A bone fracture may be diagnosed based on the history given and the physical examination performed. Radiographic imaging often is performed to confirm the diagnosis. Under certain circumstances, radiographic examination of the nearby joints is indicated in order to exclude dislocations and fracture-dislocations. In situations where projectional radiography alone is insufficient, Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) may be indicated.
In orthopedic medicine, fractures are classified in various ways. Historically they are named after the physician who first described the fracture conditions, however, there are more systematic classifications in place currently.
- Traumatic fracture – This is a fracture due to sustained trauma. e.g., fractures caused by a fall, road traffic accident, fight, etc.
- Pathologic fracture – A fracture through a bone that has been made weak by some underlying disease is called pathological fracture. e.g., a fracture through a bone weakened by metastasis. Osteoporosis is the most common cause of pathological fracture.
- Periprosthetic fracture – This is a fracture at the point of mechanical weakness at the end of an implant
- Closed fractures are those in which the overlying skin is intact
- Open/compound fractures involve wounds that communicate with the fracture, or where fracture hematoma is exposed, and may thus expose bone to contamination. Open injuries carry a higher risk of infection.
- Clean fracture
- Contaminated fracture
- Translated, or ad latus, with sideways displacement.
- Linear fracture: A fracture that is parallel to the bone's long axis
- Transverse fracture: A fracture that is at a right angle to the bone's long axis
- Oblique fracture: A fracture that is diagonal to a bone's long axis (more than 30°)
- Spiral fracture: A fracture where at least one part of the bone has been twisted
- Compression fracture/Wedge fracture: usually occurs in the vertebrae, for example when the front portion of a vertebra in the spine collapses due to osteoporosis (a medical condition which causes bones to become brittle and susceptible to fracture, with or without trauma)
- Impacted fracture: A fracture caused when bone fragments are driven into each other
- Avulsion fracture: A fracture where a fragment of bone is separated from the main mass
- Incomplete fracture: Is a fracture in which the bone fragments are still partially joined, in such cases, there is a crack in the osseous tissue that does not completely traverse the width of the bone.
- Complete fracture: Is a fracture in which bone fragments separate completely.
- Comminuted fracture: Is a fracture in which the bone has broken into several pieces.
An anatomical classification may begin with specifying the involved body part, such as the head or arm, followed with more specific localization. Fractures that have additional definition criteria than merely localization often may be classified as subtypes of fractures, such as a Holstein-Lewis fracture being a subtype of a humerus fracture. Most typical examples in an orthopedic classification given in previous section cannot be classified appropriately into any specific part of an anatomical classification, however, as they may apply to multiple anatomical fracture sites.
- Skull fracture
- Spinal fracture
- Cervical fracture
- Clay-shoveler fracture – fracture through the spinous process of a vertebra occurring at any of the lower cervical or upper thoracic vertebrae
- Burst fracture – in which a vertebra breaks from a high-energy axial load
- Compression fracture – a collapse of a vertebra, often in the form of wedge fractures due to larger compression anteriorly
- Chance fracture – compression injury to the anterior portion of a vertebral body with concomitant distraction injury to posterior elements
- Holdsworth fracture – an unstable fracture dislocation of the thoracolumbar junction of the spine
- Rib fracture
- Sternal fracture
- Shoulder fracture
- Arm fracture
- Humerus fracture (fracture of upper arm)
- Forearm fracture
- Ulnar fracture
- Radius fracture
- Essex-Lopresti fracture – a fracture of the radial head with concomitant dislocation of the distal radio-ulnar joint with disruption of the interosseous membrane 
- Distal radius fracture
- Galeazzi fracture – a fracture of the radius with dislocation of the distal radioulnar joint
- Colles' fracture – a distal fracture of the radius with dorsal (posterior) displacement of the wrist and hand
- Smith's fracture – a distal fracture of the radius with volar (ventral) displacement of the wrist and hand
- Barton's fracture – an intra-articular fracture of the distal radius with dislocation of the radiocarpal joint
- Hand fracture
- Scaphoid fracture
- Rolando fracture – a comminuted intra-articular fracture through the base of the first metacarpal bone
- Bennett's fracture – a fracture of the base of the first metacarpal bone which extends into the carpometacarpal (CMC) joint 
- Boxer's fracture – a fracture at the neck of a metacarpal
- Pelvic fracture
- Femoral fracture
- Patella fracture
- Crus fracture
- Tibia fracture
- Pilon fracture
- Tibial plateau fracture
- Bumper fracture – a fracture of the lateral tibial plateau caused by a forced valgus applied to the knee
- Segond fracture – an avulsion fracture of the lateral tibial condyle
- Gosselin fracture – a fractures of the tibial plafond into anterior and posterior fragments 
- Toddler's fracture – an undisplaced and spiral fracture of the distal third to distal half of the tibia 
- Fibular fracture
- Maisonneuve fracture – a spiral fracture of the proximal third of the fibula associated with a tear of the distal tibiofibular syndesmosis and the interosseous membrane
- Le Fort fracture of ankle – a vertical fracture of the antero-medial part of the distal fibula with avulsion of the anterior tibiofibular ligament 
- Bosworth fracture – a fracture with an associated fixed posterior dislocation of the proximal fibular fragment that becomes trapped behind the posterior tibial tubercle; the injury is caused by severe external rotation of the ankle 
- Combined tibia and fibula fracture
- Tibia fracture
- Foot fracture
The Orthopaedic Trauma Association Committee for Coding and Classification published its classification system  in 1996, adopting a similar system to the 1987 AO Foundation system. In 2007, they extended their system, unifying the two systems regarding wrist, hand, foot, and ankle fractures.
Classifications named after peopleEdit
A number of classifications are named after the person (eponymous) who developed it.
- "Denis classification" for spinal fractures 
- "Frykman classification" for forearm fractures (fractures of radius and ulna)
- "Gustilo open fracture classification" 
- "Letournel and Judet Classification" for Acetabular fractures 
- "Neer classification" for humerus fractures 
- Seinsheimer classification, Evans-Jensen classification, Pipkin classification, and Garden classification for hip fractures
Treatment of bone fractures are broadly classified as surgical or conservative, the latter basically referring to any non-surgical procedure, such as pain management, immobilization or other non-surgical stabilization. A similar classification is open versus closed treatment, in which open treatment refers to any treatment in which the fracture site is opened surgically, regardless of whether the fracture is an open or closed fracture.
Since bone healing is a natural process that will occur most often, fracture treatment aims to ensure the best possible function of the injured part after healing. Bone fractures typically are treated by restoring the fractured pieces of bone to their natural positions (if necessary), and maintaining those positions while the bone heals. Often, aligning the bone, called reduction, in good position and verifying the improved alignment with an X-ray is all that is needed. This process is extremely painful without anesthesia, about as painful as breaking the bone itself. To this end, a fractured limb usually is immobilized with a plaster or fiberglass cast or splint that holds the bones in position and immobilizes the joints above and below the fracture. When the initial post-fracture edema or swelling goes down, the fracture may be placed in a removable brace or orthosis. If being treated with surgery, surgical nails, screws, plates, and wires are used to hold the fractured bone together more directly. Alternatively, fractured bones may be treated by the Ilizarov method which is a form of external fixator.
Occasionally smaller bones, such as phalanges of the toes and fingers, may be treated without the cast, by buddy wrapping them, which serves a similar function to making a cast. By allowing only limited movement, fixation helps preserve anatomical alignment while enabling callus formation, toward the target of achieving union.
Splinting results in the same outcome as casting in children who have a distal radius fracture with little shifting.
Surgical methods of treating fractures have their own risks and benefits, but usually surgery is performed only if conservative treatment has failed, is very likely to fail, or likely to result in a poor functional outcome. With some fractures such as hip fractures (usually caused by osteoporosis), surgery is offered routinely because non-operative treatment results in prolonged immobilisation, which commonly results in complications including chest infections, pressure sores, deconditioning, deep vein thrombosis (DVT), and pulmonary embolism, which are more dangerous than surgery. When a joint surface is damaged by a fracture, surgery is also commonly recommended to make an accurate anatomical reduction and restore the smoothness of the joint.
Infection is especially dangerous in bones, due to the recrudescent nature of bone infections. Bone tissue is predominantly extracellular matrix, rather than living cells, and the few blood vessels needed to support this low metabolism are only able to bring a limited number of immune cells to an injury to fight infection. For this reason, open fractures and osteotomies call for very careful antiseptic procedures and prophylactic use of antibiotics.
Occasionally, bone grafting is used to treat a fracture.
Sometimes bones are reinforced with metal. These implants must be designed and installed with care. Stress shielding occurs when plates or screws carry too large of a portion of the bone's load, causing atrophy. This problem is reduced, but not eliminated, by the use of low-modulus materials, including titanium and its alloys. The heat generated by the friction of installing hardware can accumulate easily and damage bone tissue, reducing the strength of the connections. If dissimilar metals are installed in contact with one another (i.e., a titanium plate with cobalt-chromium alloy or stainless steel screws), galvanic corrosion will result. The metal ions produced can damage the bone locally and may cause systemic effects as well.
A Cochrane review of low-intensity pulsed ultrasound to speed healing in newly broken bones found insufficient evidence to justify routine use. Other reviews have found tentative evidence of benefit. It may be an alternative to surgery for established nonunions.
Vitamin D supplements combined with additional calcium marginally reduces the risk of hip fractures and other types of fracture in older adults; however, vitamin D supplementation alone did not reduce the risk of fractures.
Some fractures may lead to serious complications including a condition known as compartment syndrome. If not treated, eventually, compartment syndrome may require amputation of the affected limb. Other complications may include non-union, where the fractured bone fails to heal or mal-union, where the fractured bone heals in a deformed manner.
Complications of fractures may be classified into three broad groups, depending upon their time of occurrence. These are as follows –
- Immediate complications – occurs at the time of the fracture
- Early complications – occurring in the initial few days after the fracture
- Late complications – occurring a long time after the fracture
|Immediate complications||Early complications||Late complications|
||Imperfect union of the fracture
In children, whose bones are still developing, there are risks of either a growth plate injury or a greenstick fracture.
- A greenstick fracture occurs due to mechanical failure on the tension side. That is, since the bone is not so brittle as it would be in an adult, it does not completely fracture, but rather exhibits bowing without complete disruption of the bone's cortex in the surface opposite the applied force.
- Growth plate injuries, as in Salter-Harris fractures, require careful treatment and accurate reduction to make sure that the bone continues to grow normally.
- Plastic deformation of the bone, in which the bone permanently bends, but does not break, also is possible in children. These injuries may require an osteotomy (bone cut) to realign the bone if it is fixed and cannot be realigned by closed methods.
- Certain fractures mainly occur in children, including fracture of the clavicle and supracondylar fracture of the humerus.
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