Berberine reductase (EC 1.5.1.31) is an enzyme that catalyzes the chemical reaction

berberine reductase
Identifiers
EC no.1.5.1.31
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BRENDABRENDA entry
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MetaCycmetabolic pathway
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(R)-canadine + 2 NADP+ berberine + 2 NADPH + H+

Thus, the two substrates of this enzyme are (R)-canadine and nicotinamide adenine dinucleotide phosphate ion, whereas its 3 products are berberine, nicotinamide adenine dinucleotide phosphate, and hydrogen ion.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-tetrahydroberberine:NADP+ oxidoreductase. This enzyme is also called (R)-canadine synthase.

References

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  • Bauer W, Zenk MH (1991). "Formation of (R)-configurated tetrahydroprotoberberine alkaloids in vivo and in vitro". Tetrahedron Lett. 32 (4): 487–490. doi:10.1016/S0040-4039(00)79475-5.