Benzyl-2-methyl-hydroxybutyrate dehydrogenase

In enzymology, a benzyl-2-methyl-hydroxybutyrate dehydrogenase (EC 1.1.1.217) is an enzyme that catalyzes the chemical reaction

benzyl-2-methyl-hydroxybutyrate dehydrogenase
Identifiers
EC no.1.1.1.217
CAS no.99332-62-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP+ benzyl 2-methyl-3-oxobutanoate + NADPH + H+

Thus, the two substrates of this enzyme are benzyl (2R,3S)-2-methyl-3-hydroxybutanoate and NADP+, whereas its 3 products are benzyl 2-methyl-3-oxobutanoate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase. This enzyme is also called benzyl 2-methyl-3-hydroxybutyrate dehydrogenase.

References

edit
  • Furuichi A, Akita H, Matsukura H, Oishi T, Horikoshi K (1985). "Purification and properties of an asymmetric reduction enzyme of 2-methyl-3-oxobutyrate in baker's yeast". Agric. Biol. Chem. 49 (9): 2563–2570. doi:10.1271/bbb1961.49.2563.