He studied medicine in Paris, and in 1850 became a surgeon of Parisian hospitals. During his career, he practiced surgery at the Lourcine, Cochin, Hôpital Saint-Louis and Hôtel-Dieu. In 1868 he became a member of the French Académie Nationale de Médecine.
In 1870, Guérin introduced the practice of using cotton-wool bandages for prevention of wound infections. He described a horizontal fracture of the maxilla immediately above the teeth and palate, that is known today as a "Le Fort I fracture", or sometimes as a "Guérin fracture".
- De la fièvre purulente, (doctoral thesis) Paris, 1847.
- Eléments de chirurgie opératoire, ou traité pratique des opérations. Paris, 1855; fourth edition, Paris, Lauwereyns, 1870.
- Maladies des organes génitaux externes de la femme. Leçons cliniques sur les maladies des organes génitaux internes de la femme. Paris, Vve. A. Delahaye & Cie. 1878.
- Who Named It (bibliography)
- Media related to Alphonse Guérin at Wikimedia Commons