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Allura Red AC

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Allura Red AC is a red azo dye that goes by several names.[1] It is used as a food dye and has the E number E129.

Allura Red AC
Allura Red AC Structural Formula V1.png
Names
IUPAC name
Disodium 6-hydroxy-5-[(2-methoxy-5-methyl-4-sulfophenyl)azo]-2-naphthalenesulfonate
Other names
Allura Red; Food Red 17; C.I. 16035; FD&C Red 40; E129; 2-Naphthalenesulfonic acid, 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfophenyl)azo)-, disodium salt, Food Red 17, C.I. 16035, FD&C Red 40
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.043.047
E number E129 (colours)
UNII
Properties
C18H14N2Na2O8S2
Molar mass 496.42 g·mol−1
Appearance Red powder
Melting point > 300 °C (572 °F; 573 K)
Hazards
NFPA 704
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g., canola oilHealth code 1: Exposure would cause irritation but only minor residual injury. E.g., turpentineReactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogenSpecial hazards (white): no codeNFPA 704 four-colored diamond
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
No verify (what is YesYNo ?)
Infobox references

It is usually supplied as its red sodium salt, but can also be used as the calcium and potassium salts. These salts are soluble in water. In solution, its maximum absorbance lies at about 504 nm.[2]:921

Contents

Use as food colorEdit

Allura Red AC is a popular dye throughout the world. Annual production in 1980 was greater than 2.3 million kilograms.[3]

The European Union approves Allura Red AC as a food colorant, but EU countries' local laws banning food colorants are preserved.[4] In the United States, Allura Red AC is approved by the FDA for use in cosmetics, drugs, and food. When prepared as a lake it is disclosed as Red 40 Lake or Red 40 Aluminum Lake. It is used in some tattoo inks and is used in many products, such as soft drinks, cherry flavored products, children's medications, and cotton candy. It is by far the most commonly used red dye in the United States, completely replacing amaranth (Red 2) and also replacing erythrosine (Red 3) in most applications due to the potential health effects of the two dyes.

Studies on safetyEdit

 
Allura Red AC in strawberry soft drink
 
Allura Red AC in confectionery

Allura Red has been heavily studied by food safety groups in North America and Europe, but remains in wide use and wide acceptance.

The UK FSA commissioned a study of six food dyes (Tartrazine, Allura Red, Ponceau 4R, Quinoline Yellow WS, Sunset Yellow, Carmoisine (dubbed the "Southampton 6")), and sodium benzoate (a preservative) on children in the general population, who consumed them in beverages.[5][6] The study found "a possible link between the consumption of these artificial colours and a sodium benzoate preservative and increased hyperactivity" in the children;[5][6] the advisory committee to the FSA that evaluated the study also determined that because of study limitations, the results could not be extrapolated to the general population, and further testing was recommended".[5]

The European regulatory community, with a stronger emphasis on the precautionary principle, required labelling and temporarily reduced the acceptable daily intake (ADI) for the food colorings; the UK FSA called for voluntary withdrawal of the colorings by food manufacturers.[5][6] However, in 2009 the EFSA re-evaluated the data at hand and determined that "the available scientific evidence does not substantiate a link between the color additives and behavioral effects"[5] and in 2014 after further review of the data, the EFSA restored the prior ADI levels.[7] In 2015, the EFSA found that the exposure estimates did not exceed the ADI of 7 mg/kg per day in any population.[8]

The US FDA did not make changes following the publication of the Southampton study, but following a citizen petition filed by the Center for Science in the Public Interest in 2008, requesting the FDA ban several food additives, the FDA commenced a review of the available evidence, and still made no changes.[5]

Allura Red AC was at one time banned in Denmark, Belgium, France, and Switzerland, and was also banned in Sweden until the country joined the European Union in 1994.[9][not in citation given] In Norway, and Iceland, it was banned between 1978 and 2001, a period in which azo dyes were only legally used in alcoholic beverages and some fish products.[10]

ReferencesEdit

  1. ^ "From Shampoo to Cereal: Seeing to the Safety of Color Additives". Archived from the original on 2008-01-15. Retrieved 2008-06-04.  "Food Color Facts". Archived from the original on 2007-10-01. Retrieved 2006-08-18. 
  2. ^ Zvi Rappoport, ed. (2004). The Chemistry of Phenols. Chichester: John Wiley & Sons. ISBN 9780470869451. 
  3. ^ Sharma, Vinita; McKone, Harold T.; Markow, Peter G. (2011). "A Global Perspective on the History, Use, and Identification of Synthetic Food Dyes". Journal of Chemical Education. 88: 24–28. doi:10.1021/ed100545v. 
  4. ^ European Parliament and Council Directive 94/36/EC of 30 June 1994 on colours for use in foodstuffs
  5. ^ a b c d e f FDA. Background Document for the Food Advisory Committee: Certified Color Additives in Food and Possible Association with Attention Deficit Hyperactivity Disorder in Children: March 30-31, 2011
  6. ^ a b c Sarah Chapman of Chapman Technologies on behalf of Food Standards Agency in Scotland. March 2011 [Guidelines on approaches to the replacement of Tartrazine, Allura Red, Ponceau 4R, Quinoline Yellow, Sunset Yellow and Carmoisine in food and beverages]
  7. ^ EFSA Panel on Food Additives and Nutrient Sources added to food (ANS) Reconsideration of the temporary ADI and refined exposure assessment for Sunset Yellow FCF (E 110) EFSA Journal 2014;12(7):3765 . doi:10.2903/j.efsa.2014.3765
  8. ^ http://www.efsa.europa.eu/en/efsajournal/pub/4007
  9. ^ "E129", UK Food Guide, a British food additives website. Last retrieved 20 May 2007.
  10. ^ Norwegian Food Safety Authority

External linksEdit