Erythrosine, also known as Red No. 3, is an organoiodine compound, specifically a derivative of fluorone. It is a red dye which is primarily used for food coloring. It is the disodium salt of 2,4,5,7-tetraiodofluorescein. Its maximum absorbance is at 530 nm in an aqueous solution, and it is subject to photodegradation.
3D model (JSmol)
|E number||E127 (colours)|
CompTox Dashboard (EPA)
|Molar mass||879.86 g/mol|
|Melting point||142 to 144 °C (288 to 291 °F; 415 to 417 K)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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It is used as a:
- food coloring
- printing ink
- biological stain
- dental plaque disclosing agent
- radiopaque medium
- sensitizer for orthochromatic photographic films
Erythrosine is commonly used in sweets such as some candies and popsicles, and even more widely used in cake-decorating gels. It is also used to color pistachio shells. As a food additive, it has the E number E127.
Health effects of ErythrosineEdit
As a result of efforts begun in the 1970s, in 1990 the U.S. FDA had instituted a partial ban on erythrosine, citing research that high doses have been found to cause cancer in rats. In June 2008, the Center for Science in the Public Interest (CSPI) petitioned the FDA for a complete ban on erythrosine in the United States.
A series of toxicology tests combined with a review of other reported studies concluded that erythrosine is non-genotoxic and the above-mentioned increase in tumors is caused by a non-genotoxic mechanism.
A 1990 study concluded that "chronic erythrosine ingestion may promote thyroid tumor formation in rats via chronic stimulation of the thyroid by TSH." with 4% of total daily dietary intake consisting of Erythrosine B 
Regulation and prevalenceEdit
While DS commonly used in many countries of the world, erythrosine is less commonly used in the United States (the second least used after Fast Green FCF) because Allura Red AC (Red #40) is generally used instead. However, Allura Red AC is banned in many European countries because it is an azo dye. Erythrosine can be used in colored food and ingested drugs in the USA without any restriction, however, its use is banned in cosmetics and external drugs. The lake variant is also banned from use in the United States.
Erythrosine B; Erythrosin B; Acid Red 51; C.I. 45430; FD & C Red No.3; E127; 2',4',5',7'-Tetraiodo-3',6'-dihydroxy-spiro[3H-isobenzofuran-1,9'-xanthen]-3-one disodium salt; Tetraiodofluorescein Sodium Salt; Calcoid Erythrosine N; 2,4,5,7-Tetraiodo-3,6-dihydroxyxanthene-9-spiro-1'-3H-isobenzofuran-3'-one disodium salt; 2',4',5',7'-Tetraiodofluorescein, disodium salt; C.I.Food Red 14; Aizen Erythrosine; Tetraiodifluorescein, disodium salt; Spiro[isobenzofuran- 1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium salt.
It is listed under the following number systems:
- Phyllis A. Lyday "Iodine and Iodine Compounds" in Ullmann's Encyclopedia of Industrial Chemistry, 2005, Wiley-VCH, Weinheim
- "Food Color Additives". Archived from the original on 2007-01-28. Retrieved 2007-01-29.
- Chequer, Farah Maria Drumond; Venâncio, Vinícius de Paula; Bianchi, Maria de Lourdes Pires; Antunes, Lusânia Maria Greggi (October 2012). "Genotoxic and mutagenic effects of erythrosine B, a xanthene food dye, on HepG2 cells". Food and Chemical Toxicology. 50 (10): 3447–3451. doi:10.1016/j.fct.2012.07.042. PMID 22847138.
- Gurr, Edward (2012). Synthetic Dyes in Biology, Medicine And Chemistry. elsevier. pp. 197, 198.
- Dictionary of Analytical Reagents. Crc Press. 1993. p. 474.
- "Erythrosine is a potential photosensitizer for the photodynamic therapy of oral plaque biofilms". Journal of Antimicrobial Chemotherapy. 57 (4). January 16, 2006.
- "Food Product Design Article". Archived from the original on 2007-07-23. Retrieved 2008-09-06.
- Blue Diamond Ultra Premium Blend Mixed Nuts, distributed by Diamond Foods, Inc. Stockton, CA
- FDA: Red Dye's Reluctant Regulator; Partial Ban Points to Limitations of 30-Year-Old Delaney Clause, The Washington Post, February 7, 1990[dead link]
- FDA Urged To Ban Some Food Dyes, CBS News, June 3, 2008
- Lin, George H. Y.; Brusick, David J. (1986). "Mutagenicity studies on FD&C Red No.3". Mutagenesis. 1 (4): 253–259. doi:10.1093/mutage/1.4.253. PMID 2457780.
- Jennings, A. S.; Schwartz S. L.; Balter N. J.; Gardner D; Witorsch R. J. (May 1990). "Effects of oral erythrosine (2',4',5',7'-tetraiodofluorescein) on the pituitary-thyroid axis in rats". Toxicology and Applied Pharmacology. 103 (3): 549–56. doi:10.1016/0041-008x(90)90327-q. PMID 2160137.
- European Ban on Certain Azo Dyes Archived August 13, 2012, at the Wayback Machine
- "Color Additive Status List". Food & Drug Administration. December 2015. Retrieved May 16, 2016.
- Erythrosin B Archived 2010-03-17 at the Wayback Machine, University of South Carolina
- Erythrosine, chemicalland21.com