8-oxocoformycin reductase

In enzymology, a 8-oxocoformycin reductase (EC 1.1.1.235) is an enzyme that catalyzes the chemical reaction

8-oxocoformycin reductase
Identifiers
EC no.1.1.1.235
CAS no.114995-16-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
coformycin + NADP+ 8-oxocoformycin + NADPH + H+

Thus, the two substrates of this enzyme are coformycin and NADP+, whereas its 3 products are 8-oxocoformycin, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is coformycin:NADP+ 8-oxidoreductase. This enzyme is also called 8-ketodeoxycoformycin reductase.

References

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  • Hanvey JC, Hawkins ES, Baker DC, Suhadolnik RJ (July 1988). "8-Ketodeoxycoformycin and 8-ketocoformycin as intermediates in the biosynthesis of 2'-deoxycoformycin and coformycin". Biochemistry. 27 (15): 5790–5. doi:10.1021/bi00415a059. PMID 3052586.