In enzymology, a 7beta-hydroxysteroid dehydrogenase (NADP+) (EC 1.1.1.201) is an enzyme that catalyzes the chemical reaction
| 7-beta-hydroxysteroid dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.201 | ||||||||
| CAS no. | 79393-83-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- a 7beta-hydroxysteroid + NADP+ a 7-oxosteroid + NADPH + H+
Thus, the two substrates of this enzyme are 7beta-hydroxysteroid and NADP+, whereas its 3 products are 7-oxosteroid, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7beta-hydroxysteroid:NADP+ 7-oxidoreductase. Other names in common use include NADP+-dependent 7beta-hydroxysteroid dehydrogenase, and 7beta-hydroxysteroid dehydrogenase (NADP+).
References edit
- Savino S, Ferrandi EE, Forneris F, Rovida S, Riva S, Monti D, Mattevi A (June 2016). "Structural and biochemical insights into 7β-hydroxysteroid dehydrogenase stereoselectivity". Proteins. 84 (6): 859–65. doi:10.1002/prot.25036. PMID 27006087. S2CID 36310113.
- Hirano S, Masuda N (May 1982). "Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens". Applied and Environmental Microbiology. 43 (5): 1057–63. Bibcode:1982ApEnM..43.1057H. doi:10.1128/AEM.43.5.1057-1063.1982. PMC 244185. PMID 6954878.
- MacDonald IA, Roach PD (August 1981). "Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum". Biochimica et Biophysica Acta. 665 (2): 262–9. doi:10.1016/0005-2760(81)90011-4. PMID 6945134.
- MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV (November 1982). "Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms". Applied and Environmental Microbiology. 44 (5): 1187–95. Bibcode:1982ApEnM..44.1187M. doi:10.1128/AEM.44.5.1187-1195.1982. PMC 242167. PMID 6758698.
