In enzymology, a 3-deoxyoctulosonase (EC 3.2.1.144) is an enzyme that catalyzes the chemical reaction

3-deoxyoctulosonase
Identifiers
EC no.3.2.1.144
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
3-deoxyoctulosonyl-lipopolysaccharide + H2O 3-deoxyoctulosonic acid + lipopolysaccharide

Thus, the two substrates of this enzyme are 3-deoxyoctulosonyl-lipopolysaccharide and H2O, whereas its two products are 3-deoxyoctulosonic acid and lipopolysaccharide.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is 3-deoxyoctulosonyl-lipopolysaccharide hydrolase. This enzyme is also called alpha-Kdo-ase.

References

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  • Li YT, Wang LX, Pavlova NV, Li SC, Lee YC (October 1997). "alpha-KDOase activity in oyster and synthesis of alpha- and beta-4-methylumbelliferyl ketosides of 3-deoxy-D-manno-octulosonic acid". The Journal of Biological Chemistry. 272 (42): 26419–24. doi:10.1074/jbc.272.42.26419. PMID 9334217.