Three-time defending champion Diede de Groot[1] defeated Yui Kamiji in the final, 6–3, 6–2 to win the women's singles wheelchair tennis title at the 2021 US Open. With the win, she completed the Golden Slam, becoming the first wheelchair tennis player to do so (alongside Dylan Alcott in the quad singles event).
| Wheelchair women's singles | |
|---|---|
| 2021 US Open | |
| Champion |  Diede de Groot |
| Runner-up |  Yui Kamiji |
| Score | 6–3, 6–2 |
| Draw | 8 |
| Seeds | 2 |
Seeds edit
Diede de Groot (champion)
Yui Kamiji (final)
Draw edit
Key edit
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Finals edit
| Quarterfinals | Semifinals | Final | ||||||||||||||||||
| 1 | Diede de Groot
| 6 | 6 | |||||||||||||||||
 Angélica Bernal
| 2 | 0 | ||||||||||||||||||
| 1 | Diede de Groot
| 6 | 6 | |||||||||||||||||
| Aniek van Koot
| 1 | 0 | ||||||||||||||||||
| Aniek van Koot
| 6 | 6 | ||||||||||||||||||
| WC |  Dana Mathewson
| 1 | 2 | |||||||||||||||||
| 1 | Diede de Groot
| 6 | 6 | |||||||||||||||||
| 2 | Yui Kamiji
| 3 | 2 | |||||||||||||||||
| Momoko Ohtani
| 1 | 7 | 3 | |||||||||||||||||
 Jordanne Whiley
| 6 | 5 | 6 | |||||||||||||||||
| Jordanne Whiley
| 1 | 3 | ||||||||||||||||||
| 2 | Yui Kamiji
| 6 | 6 | |||||||||||||||||
 Kgothatso Montjane
| 612 | 2 | ||||||||||||||||||
| 2 | Yui Kamiji
| 714 | 6 | |||||||||||||||||