- 26 October: earthquake measuring 5.9 on the Richter scale in Central Italy with its epicenter between Castelsantangelo sul Nera, Visso and Ussita.
- 30 October: Earthquake measuring 6.5 on the Richter scale in Central Italy with its epicenter between Norcia and Preci.
- 7 December: Prime Minister Matteo Renzi resigns in the hands of the President of the Republic Sergio Mattarella following the defeat in the referendum on 4 December.
- 12 December: Paolo Gentiloni assumes the office of President of the Council of Ministers.
- 22 December: the Salerno-Reggio Calabria motorway is completed and renamed the Mediterranean motorway.
- January 7 – Valerio Zanone, 79, politician
- January 14 – Franco Citti, 80, actor
- January 19 – Ettore Scola, 84, director
- February 19 – Umberto Eco, 82, philosopher and semiotician
- March 25 – Paolo Poli, 86, theatre actor
- May 19 – Marco Pannella, 86, politician
- May 28 – Giorgio Albertazzi, 92, actor and director
- June 5 – Gianluca Buonanno, 50, politician
- June 27 – Bud Spencer, 86, actor
- July 13 – Bernardo Provenzano, 83, criminal and chief of the Sicilian Mafia
- September 16 – Carlo Azeglio Ciampi, 95, former President
- October 13 – Dario Fo, 90, actor and Nobel Prize laureate
- November 1 – Tina Anselmi, 89, politician
- November 8 – Umberto Veronesi, 90, scientist
